Cadmium in arterial hypertension pathogenesis

Abstract

The study presents epidemiological data, clinical observations and experimental studies on the role of cadmium (Cd) in arterial hypertension induction. Clinical and experimental examinations point to the possibility of arterial hypertension development both in occupational and environmental exposure to Cd, whereas the results of epidemiological studies are not unequivocal. Among various mechanisms of the development of hypertension during exposure to Cd, its toxic effect on vessels and the changes of their reactivity (probably connected with oxidative stress), play the decisive role.