open access

Vol 8, No 1 (2004)
REVIEV
Published online: 2004-01-23
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The role of adipocyte products in progress of insulin resistance in obese and hypertensive patients

Monika Szulińska, Danuta Pupek-Musialik, Paweł Bogdański
Nadciśnienie tętnicze 2004;8(1):33-40.

open access

Vol 8, No 1 (2004)
REVIEV
Published online: 2004-01-23

Abstract

Hypertension and obesity are very important medical and social problems. On the basis of experimental and clinical studies strong relationship between obesity and hypertension has been confirmed. Insulin resistance plays a fundamental role in complex pathogenesis of obesity related hypertension.
In the view of recent studies adipose tissue should be treated as endocrine organ producing many active substances. It is postulated that some of them (tumor necrosis factor α, leptin, adiponectin, resistin, interleukin-6) can play potential role in the mechanism leading to insulin resistance.
Better understanding of pathomechanism leading to the development of insulin resistance could contribute to improvement of therapeutic process.

Abstract

Hypertension and obesity are very important medical and social problems. On the basis of experimental and clinical studies strong relationship between obesity and hypertension has been confirmed. Insulin resistance plays a fundamental role in complex pathogenesis of obesity related hypertension.
In the view of recent studies adipose tissue should be treated as endocrine organ producing many active substances. It is postulated that some of them (tumor necrosis factor α, leptin, adiponectin, resistin, interleukin-6) can play potential role in the mechanism leading to insulin resistance.
Better understanding of pathomechanism leading to the development of insulin resistance could contribute to improvement of therapeutic process.
Get Citation

Keywords

insulin resistance; adipose tissue; TNF-alfa; adiponectin; resistin adiponectin; leptin

About this article
Title

The role of adipocyte products in progress of insulin resistance in obese and hypertensive patients

Journal

Arterial Hypertension

Issue

Vol 8, No 1 (2004)

Pages

33-40

Published online

2004-01-23

Bibliographic record

Nadciśnienie tętnicze 2004;8(1):33-40.

Keywords

insulin resistance
adipose tissue
TNF-alfa
adiponectin
resistin adiponectin
leptin

Authors

Monika Szulińska
Danuta Pupek-Musialik
Paweł Bogdański

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