Vol 11, No 2 (2007)
Editorial
Published online: 2007-05-18
Arterial hypertension and type 1 diabetes mellitus
Paweł Uruski, Aleksandra Uruska, Dorota Zozulińska, Andrzej Tykarski
Nadciśnienie tętnicze 2007;11(2):85-94.
Vol 11, No 2 (2007)
Artykuły redakcyjne
Published online: 2007-05-18
Abstract
Arterial hypertension in patients with type 1 diabetes, due to diagnosis and treatment, remains heavyweight clinical
problem. In comparison with general population, hypertension in this group of patients, is more common and
more malignant. It is connected with increased risk of macroangiopathy and microangiopathy, and cardiovascular
deaths in young people. Pathogenesis of arterial hypertension in patients with type 1 diabetes, despite of the predominant role of diabetic nephropathy, is multifactorial and closely related to metabolic control of diabetes. Lack of big clinical trials considering this issue and unspecified guidelines of scientific associations, cause that treatment of hypertension in this group of patients has empirical character. Therefore at assortment of antihypertensive drugs in this patients we have to take under consideration, beside conclusions from studies on type 2 diabetes, also etiopathogenesis of the disease and usually young age of these patients and also particular conditionings (intensive insulinotherapy) and clinical
situations typical for this group of patients e.g. higher risk of hypoglycaemia and possibility or plans of geting pregnant in young women. Antihypertensive drugs of first
choice in DM 1 are ACEI, and ARB are only alternative in case of side effects. In medical care of patients with DM 1 and blood pressure disturbances cooperation between
diabetologists and specialists in hypertension is necessary.
Abstract
Arterial hypertension in patients with type 1 diabetes, due to diagnosis and treatment, remains heavyweight clinical
problem. In comparison with general population, hypertension in this group of patients, is more common and
more malignant. It is connected with increased risk of macroangiopathy and microangiopathy, and cardiovascular
deaths in young people. Pathogenesis of arterial hypertension in patients with type 1 diabetes, despite of the predominant role of diabetic nephropathy, is multifactorial and closely related to metabolic control of diabetes. Lack of big clinical trials considering this issue and unspecified guidelines of scientific associations, cause that treatment of hypertension in this group of patients has empirical character. Therefore at assortment of antihypertensive drugs in this patients we have to take under consideration, beside conclusions from studies on type 2 diabetes, also etiopathogenesis of the disease and usually young age of these patients and also particular conditionings (intensive insulinotherapy) and clinical
situations typical for this group of patients e.g. higher risk of hypoglycaemia and possibility or plans of geting pregnant in young women. Antihypertensive drugs of first
choice in DM 1 are ACEI, and ARB are only alternative in case of side effects. In medical care of patients with DM 1 and blood pressure disturbances cooperation between
diabetologists and specialists in hypertension is necessary.
Keywords
arterial hypertension; diabetes mellitus type 1; pathophysiology; antihypertensive treatment
Title
Arterial hypertension and type 1 diabetes mellitus
Journal
Arterial Hypertension
Issue
Vol 11, No 2 (2007)
Article type
Editorial
Pages
85-94
Published online
2007-05-18
Page views
680
Article views/downloads
3452
Bibliographic record
Nadciśnienie tętnicze 2007;11(2):85-94.
Keywords
arterial hypertension
diabetes mellitus type 1
pathophysiology
antihypertensive treatment
Authors
Paweł Uruski
Aleksandra Uruska
Dorota Zozulińska
Andrzej Tykarski
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