open access

Vol 12, No 2 (2008)
Prace oryginalne
Published online: 2008-04-03
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Associations between adipocytokines and metabolic disturbances in obese adolescents - preliminary results

Joanna Chrzanowska, Agnieszka Zubkiewicz-Kucharska, Anna Noczyńska
Nadciśnienie tętnicze 2008;12(2):94-100.

open access

Vol 12, No 2 (2008)
Prace oryginalne
Published online: 2008-04-03

Abstract


Background The purpose of our study was to evaluate associations between metabolic syndrome’s components, insulin resistance and adipocytokines in obese teenagers.
Material and methods We examined 99 overweight and obese children, aged 10-18 years (mean 14.3 ± 1.8) diagnosed and treated in Department of Pediatric Endocrinology and Diabetology, Medical University of Wrocław. BMI, waist circumference, blood pressure, OGTT with insulin levels, HOMA-IR, total cholesterol, HDL, LDL and triglycerides levels were taken into account. Moreover adiponectin and resistin were estimated. Insulin resistance was diagnosed if HOMA-IR > 2.5. Metabolic syndrome (MetS) was diagnosed according to IDF.
Results MetS was diagnosed in 36.36% of children. Insulin resistance was diagnosed in 67.67% of children: in 86.11% children with MetS and 55.5% children without MetS. In the MetS group lower concentration of adiponectin was observed.
Conclusions
1. Insulin resistance is observed in obese adolescents, more frequently in patients with metabolic syndrome.
2. Adiponectin is a sensitive marker for insulin resistance and metabolic syndrome.

Abstract


Background The purpose of our study was to evaluate associations between metabolic syndrome’s components, insulin resistance and adipocytokines in obese teenagers.
Material and methods We examined 99 overweight and obese children, aged 10-18 years (mean 14.3 ± 1.8) diagnosed and treated in Department of Pediatric Endocrinology and Diabetology, Medical University of Wrocław. BMI, waist circumference, blood pressure, OGTT with insulin levels, HOMA-IR, total cholesterol, HDL, LDL and triglycerides levels were taken into account. Moreover adiponectin and resistin were estimated. Insulin resistance was diagnosed if HOMA-IR > 2.5. Metabolic syndrome (MetS) was diagnosed according to IDF.
Results MetS was diagnosed in 36.36% of children. Insulin resistance was diagnosed in 67.67% of children: in 86.11% children with MetS and 55.5% children without MetS. In the MetS group lower concentration of adiponectin was observed.
Conclusions
1. Insulin resistance is observed in obese adolescents, more frequently in patients with metabolic syndrome.
2. Adiponectin is a sensitive marker for insulin resistance and metabolic syndrome.
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Keywords

obesity; insulin resistance; adiponectin; resisitin

About this article
Title

Associations between adipocytokines and metabolic disturbances in obese adolescents - preliminary results

Journal

Arterial Hypertension

Issue

Vol 12, No 2 (2008)

Pages

94-100

Published online

2008-04-03

Bibliographic record

Nadciśnienie tętnicze 2008;12(2):94-100.

Keywords

obesity
insulin resistance
adiponectin
resisitin

Authors

Joanna Chrzanowska
Agnieszka Zubkiewicz-Kucharska
Anna Noczyńska

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