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Associations between adipocytokines and metabolic disturbances in obese adolescents - preliminary results
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Abstract
Background The purpose of our study was to evaluate associations between metabolic syndrome’s components, insulin resistance and adipocytokines in obese teenagers.
Material and methods We examined 99 overweight and obese children, aged 10-18 years (mean 14.3 ± 1.8) diagnosed and treated in Department of Pediatric Endocrinology and Diabetology, Medical University of Wrocław. BMI, waist circumference, blood pressure, OGTT with insulin levels, HOMA-IR, total cholesterol, HDL, LDL and triglycerides levels were taken into account. Moreover adiponectin and resistin were estimated. Insulin resistance was diagnosed if HOMA-IR > 2.5. Metabolic syndrome (MetS) was diagnosed according to IDF.
Results MetS was diagnosed in 36.36% of children. Insulin resistance was diagnosed in 67.67% of children: in 86.11% children with MetS and 55.5% children without MetS. In the MetS group lower concentration of adiponectin was observed.
Conclusions
1. Insulin resistance is observed in obese adolescents, more frequently in patients with metabolic syndrome.
2. Adiponectin is a sensitive marker for insulin resistance and metabolic syndrome.
Abstract
Background The purpose of our study was to evaluate associations between metabolic syndrome’s components, insulin resistance and adipocytokines in obese teenagers.
Material and methods We examined 99 overweight and obese children, aged 10-18 years (mean 14.3 ± 1.8) diagnosed and treated in Department of Pediatric Endocrinology and Diabetology, Medical University of Wrocław. BMI, waist circumference, blood pressure, OGTT with insulin levels, HOMA-IR, total cholesterol, HDL, LDL and triglycerides levels were taken into account. Moreover adiponectin and resistin were estimated. Insulin resistance was diagnosed if HOMA-IR > 2.5. Metabolic syndrome (MetS) was diagnosed according to IDF.
Results MetS was diagnosed in 36.36% of children. Insulin resistance was diagnosed in 67.67% of children: in 86.11% children with MetS and 55.5% children without MetS. In the MetS group lower concentration of adiponectin was observed.
Conclusions
1. Insulin resistance is observed in obese adolescents, more frequently in patients with metabolic syndrome.
2. Adiponectin is a sensitive marker for insulin resistance and metabolic syndrome.
Keywords
obesity; insulin resistance; adiponectin; resisitin
About this articleTitle
Associations between adipocytokines and metabolic disturbances in obese adolescents - preliminary results
Journal
Issue
Article type
Original paper
Pages
94-100
Published online
2008-04-03
Bibliographic record
Nadciśnienie tętnicze 2008;12(2):94-100.
Keywords
obesity
insulin resistance
adiponectin
resisitin
Authors
Joanna Chrzanowska
Agnieszka Zubkiewicz-Kucharska
Anna Noczyńska