Associations between adipocytokines and metabolic disturbances in obese adolescents - preliminary results

Abstract

Background The purpose of our study was to evaluate associations between metabolic syndrome’s components, insulin resistance and adipocytokines in obese teenagers.
Material and methods We examined 99 overweight and obese children, aged 10-18 years (mean 14.3 ± 1.8) diagnosed and treated in Department of Pediatric Endocrinology and Diabetology, Medical University of Wrocław. BMI, waist circumference, blood pressure, OGTT with insulin levels, HOMA-IR, total cholesterol, HDL, LDL and triglycerides levels were taken into account. Moreover adiponectin and resistin were estimated. Insulin resistance was diagnosed if HOMA-IR > 2.5. Metabolic syndrome (MetS) was diagnosed according to IDF.
Results MetS was diagnosed in 36.36% of children. Insulin resistance was diagnosed in 67.67% of children: in 86.11% children with MetS and 55.5% children without MetS. In the MetS group lower concentration of adiponectin was observed.
Conclusions
1. Insulin resistance is observed in obese adolescents, more frequently in patients with metabolic syndrome.
2. Adiponectin is a sensitive marker for insulin resistance and metabolic syndrome.