open access

Vol 12, No 6 (2008)
Prace oryginalne
Published online: 2008-12-11
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Leptin and insulin concentrations, lipid profile and anthropometric parameters in young adults with primary arterial hypertension

Agata Strażyńska, Wiesław Bryl, Karolina Hoffmann, Anna Miczke, Maciej Cymerys, Aneta Rzesoś, Lucyna Kramer, Katarzyna Musialik
Nadciśnienie tętnicze 2008;12(6):424-431.

open access

Vol 12, No 6 (2008)
Prace oryginalne
Published online: 2008-12-11

Abstract


Background In subjects with primary arterial hypertension often coexists excessive body mass and metabolic abnormalities like hiperleptinemia, increased insulin resistance, higher total cholesterol and LDL-cholesterol concentrations and lower HDL-cholesterol level. The role of each of these abnormalities itself in elevation of blood pressure or arterial hypertension development remains controversial. The aim of this paper was to estimate concentrations of leptin, insulin, lipid profile and body mass index in young population with primary arterial hypertension.
Material and methods 56 patients aged 16-31 with essential arterial hypertension were qualified to this study. The control group consisted of 10 carefully selected healthy people according to sex and age. The anthropometric, blood pressure and heart rate measurements were taken. In blood serum the concentration of leptin and insulin, total cholesterol, triglycerides and LDL and HDL-cholesterol were assessed.
Results In the group of people with arterial hypertension compared to the control group significantly higher values of systolic (138.8 ± 13.2 mm Hg vs. 113.4 ± 8.4 mm Hg) and diastolic (81.9 ± 8.4 mm Hg vs. 71.4 ± 7.3 mm Hg) blood pressure, body mass (87.02 ± 25.10 kg vs. 62.93 ± 12.77 kg) and BMI (27.26 ± 6.29 kg/m² vs. 22.19 ± 3.47 kg/m²) and increased values of triglycerides (1.60 ± 1.28 mmol/l vs. 0.85 ± 0.39 mmol/l) and insulin (37.48 ± 55.77 µIU/ml vs. 16.70 ± 14.67 µIU/ml) concentrations were observed. The assessment did not reveal significant differences in leptin, total cholesterol, LDL-cholesterol, HDL-cholesterol concentrations and heart rate between the examined and the control group. The positive family history through arterial hypertension occurred more frequently in the examined group (80.3% vs. 40.0%).
Conclusions In young adults the leptin concentration correlates with BMI and insulin concentration but not with arterial hypertension. Subjects with essential arterial hypertension and excessive body mass have higher levels of insulin concentration.

Abstract


Background In subjects with primary arterial hypertension often coexists excessive body mass and metabolic abnormalities like hiperleptinemia, increased insulin resistance, higher total cholesterol and LDL-cholesterol concentrations and lower HDL-cholesterol level. The role of each of these abnormalities itself in elevation of blood pressure or arterial hypertension development remains controversial. The aim of this paper was to estimate concentrations of leptin, insulin, lipid profile and body mass index in young population with primary arterial hypertension.
Material and methods 56 patients aged 16-31 with essential arterial hypertension were qualified to this study. The control group consisted of 10 carefully selected healthy people according to sex and age. The anthropometric, blood pressure and heart rate measurements were taken. In blood serum the concentration of leptin and insulin, total cholesterol, triglycerides and LDL and HDL-cholesterol were assessed.
Results In the group of people with arterial hypertension compared to the control group significantly higher values of systolic (138.8 ± 13.2 mm Hg vs. 113.4 ± 8.4 mm Hg) and diastolic (81.9 ± 8.4 mm Hg vs. 71.4 ± 7.3 mm Hg) blood pressure, body mass (87.02 ± 25.10 kg vs. 62.93 ± 12.77 kg) and BMI (27.26 ± 6.29 kg/m² vs. 22.19 ± 3.47 kg/m²) and increased values of triglycerides (1.60 ± 1.28 mmol/l vs. 0.85 ± 0.39 mmol/l) and insulin (37.48 ± 55.77 µIU/ml vs. 16.70 ± 14.67 µIU/ml) concentrations were observed. The assessment did not reveal significant differences in leptin, total cholesterol, LDL-cholesterol, HDL-cholesterol concentrations and heart rate between the examined and the control group. The positive family history through arterial hypertension occurred more frequently in the examined group (80.3% vs. 40.0%).
Conclusions In young adults the leptin concentration correlates with BMI and insulin concentration but not with arterial hypertension. Subjects with essential arterial hypertension and excessive body mass have higher levels of insulin concentration.
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Keywords

arterial hypertension; leptin; insulin; young population

About this article
Title

Leptin and insulin concentrations, lipid profile and anthropometric parameters in young adults with primary arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 12, No 6 (2008)

Pages

424-431

Published online

2008-12-11

Bibliographic record

Nadciśnienie tętnicze 2008;12(6):424-431.

Keywords

arterial hypertension
leptin
insulin
young population

Authors

Agata Strażyńska
Wiesław Bryl
Karolina Hoffmann
Anna Miczke
Maciej Cymerys
Aneta Rzesoś
Lucyna Kramer
Katarzyna Musialik

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