open access

Vol 49, No 3 (2017)
Review articles
Published online: 2017-08-12
Submitted: 2017-07-09
Accepted: 2017-08-07
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Neutrophils, NETs, NETosis — old or new factors in sepsis and septic shock?

Małgorzata Lipinska-Gediga
DOI: 10.5603/AIT.2017.0041
·
Pubmed: 28803442
·
Anaesthesiol Intensive Ther 2017;49(3):235-240.

open access

Vol 49, No 3 (2017)
Review articles
Published online: 2017-08-12
Submitted: 2017-07-09
Accepted: 2017-08-07

Abstract

Neutrophils are an key part of the innate immune system in the host’s defences against pathogens. Circulating neutrophils are recruited at the sites of infection or sterile inflammation in response to pathogen and host-derived inflammatory mediators. In addition to phagocytosis and degranulation, neutrophils display the release of NETs in order to restrain infection. NETs are able to entrap and kill microbes, and display proinflammatory and prothrombotic properties.

Abstract

Neutrophils are an key part of the innate immune system in the host’s defences against pathogens. Circulating neutrophils are recruited at the sites of infection or sterile inflammation in response to pathogen and host-derived inflammatory mediators. In addition to phagocytosis and degranulation, neutrophils display the release of NETs in order to restrain infection. NETs are able to entrap and kill microbes, and display proinflammatory and prothrombotic properties.

Get Citation

Keywords

sepsis, neutrophils, NETs, NETosis, thrombocytes

About this article
Title

Neutrophils, NETs, NETosis — old or new factors in sepsis and septic shock?

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 49, No 3 (2017)

Pages

235-240

Published online

2017-08-12

DOI

10.5603/AIT.2017.0041

Pubmed

28803442

Bibliographic record

Anaesthesiol Intensive Ther 2017;49(3):235-240.

Keywords

sepsis
neutrophils
NETs
NETosis
thrombocytes

Authors

Małgorzata Lipinska-Gediga

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