open access

Vol 49, No 4 (2017)
Original and clinical articles
Published online: 2017-10-13
Submitted: 2017-04-09
Accepted: 2017-08-20
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Determinants of immediate failure of noninvasive mechanical ventilation outside the intensive care unit

Killen H. Briones Claudett, Monica H. Briones Claudett, Antonio M. Esquinas, Michelle Grunauer Andrade
DOI: 10.5603/AIT.a2017.0054
·
Pubmed: 29027655
·
Anaesthesiol Intensive Ther 2017;49(4):252-258.

open access

Vol 49, No 4 (2017)
Original and clinical articles
Published online: 2017-10-13
Submitted: 2017-04-09
Accepted: 2017-08-20

Abstract

BACKGROUND: This study aimed to characterize which are the early determinants of immediate failure of the use of noninvasive mechanical ventilation (NIMV) outside the ICU.

METHODS: This prospective study included patients who were admitted to the Military Hospital in Guayaquil, Ecuador. Each variable was analyzed independently by using a multiple logistic regression model toward establishing an association with the event.

RESULTS: A total of 249 cases of NIMV over a 10 year period of its application outside the ICU was included in the study. Fifty-five (22.10%) patients were transferred to the ICU, A multivariate analysis showed that the determinants of immediate NIMV failure outside the ICU were the following: age (OR: 1.12; P = 0.03); SBP (OR: 1.04; P = 0.001); HR (OR: 1.66; P < 0.0001); pCO2 (OR: 1.16; P = 0.007); pO2 (OR: 1.35; P = 0.003); levels of IPAP (OR: 1.35; P < 0.0001); and the number of quadrants affected, as shown in a chest X-ray (OR: 1.40; P < 0.0001).

CONCLUSIONS: The number of affected quadrants in a chest X-ray, tachyarrhythmia and hypoxemia may be useful in the initial decision in the use of NIMV outside the ICU. High values of IPAP, the persistence of elevated pCO2, arterial hypotension, and age could be useful as a second screening associated with immediate NIMV failure outside the ICU.

Abstract

BACKGROUND: This study aimed to characterize which are the early determinants of immediate failure of the use of noninvasive mechanical ventilation (NIMV) outside the ICU.

METHODS: This prospective study included patients who were admitted to the Military Hospital in Guayaquil, Ecuador. Each variable was analyzed independently by using a multiple logistic regression model toward establishing an association with the event.

RESULTS: A total of 249 cases of NIMV over a 10 year period of its application outside the ICU was included in the study. Fifty-five (22.10%) patients were transferred to the ICU, A multivariate analysis showed that the determinants of immediate NIMV failure outside the ICU were the following: age (OR: 1.12; P = 0.03); SBP (OR: 1.04; P = 0.001); HR (OR: 1.66; P < 0.0001); pCO2 (OR: 1.16; P = 0.007); pO2 (OR: 1.35; P = 0.003); levels of IPAP (OR: 1.35; P < 0.0001); and the number of quadrants affected, as shown in a chest X-ray (OR: 1.40; P < 0.0001).

CONCLUSIONS: The number of affected quadrants in a chest X-ray, tachyarrhythmia and hypoxemia may be useful in the initial decision in the use of NIMV outside the ICU. High values of IPAP, the persistence of elevated pCO2, arterial hypotension, and age could be useful as a second screening associated with immediate NIMV failure outside the ICU.

Get Citation

Keywords

mechanical ventilation, noninvasive; intensive care unit, out-of intensive care unit

About this article
Title

Determinants of immediate failure of noninvasive mechanical ventilation outside the intensive care unit

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 49, No 4 (2017)

Pages

252-258

Published online

2017-10-13

DOI

10.5603/AIT.a2017.0054

Pubmed

29027655

Bibliographic record

Anaesthesiol Intensive Ther 2017;49(4):252-258.

Keywords

mechanical ventilation
noninvasive
intensive care unit
out-of intensive care unit

Authors

Killen H. Briones Claudett
Monica H. Briones Claudett
Antonio M. Esquinas
Michelle Grunauer Andrade

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