open access

Vol 50, No 3 (2018)
Review articles
Published online: 2018-07-12
Submitted: 2017-04-01
Accepted: 2018-04-30
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Multiple electrode aggregometry as a method for platelet function assessment according to the European guidelines.

Jan Pluta, Barbara Nicińska, Janusz Trzebicki
DOI: 10.5603/AIT.a2018.0024
·
Pubmed: 30001456
·
Anaesthesiol Intensive Ther 2018;50(3):230-233.

open access

Vol 50, No 3 (2018)
Review articles
Published online: 2018-07-12
Submitted: 2017-04-01
Accepted: 2018-04-30

Abstract

Platelets play an essential role in haemostasis. Assessment of their function is vital for anaesthesiologists evaluating haemostatic potential, especially during emergency operations. The monitoring of platelets function had been implemented into the European recommendations for management of perioperative and posttraumatic bleeding. One of the diagnostic methods described in the recommendations is multiple electrode aggregometry. As antiplatelet therapy becomes more widely used in modern medicine, this method, in contrast to standard laboratory tests, can significantly help to identify patients with drug-induced thrombocytopaty. The aggregometry enables prompt evaluation of the platelets aggregation which is very useful for everyday decision-making in goal-directed hemostatic therapy.

Abstract

Platelets play an essential role in haemostasis. Assessment of their function is vital for anaesthesiologists evaluating haemostatic potential, especially during emergency operations. The monitoring of platelets function had been implemented into the European recommendations for management of perioperative and posttraumatic bleeding. One of the diagnostic methods described in the recommendations is multiple electrode aggregometry. As antiplatelet therapy becomes more widely used in modern medicine, this method, in contrast to standard laboratory tests, can significantly help to identify patients with drug-induced thrombocytopaty. The aggregometry enables prompt evaluation of the platelets aggregation which is very useful for everyday decision-making in goal-directed hemostatic therapy.

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Keywords

haemostasis, platelets, bleeding, thrombocytopathy, multiple electrode aggregometry

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About this article
Title

Multiple electrode aggregometry as a method for platelet function assessment according to the European guidelines.

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 50, No 3 (2018)

Pages

230-233

Published online

2018-07-12

DOI

10.5603/AIT.a2018.0024

Pubmed

30001456

Bibliographic record

Anaesthesiol Intensive Ther 2018;50(3):230-233.

Keywords

haemostasis
platelets
bleeding
thrombocytopathy
multiple electrode aggregometry

Authors

Jan Pluta
Barbara Nicińska
Janusz Trzebicki

References (25)
  1. BORN GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962; 194: 927–929.
  2. Born G, Cross MJ. The aggregation of blood platelets. J Physiol . 1963; 168(1): 178–195.
  3. Syska K, Kosiorek A, Podsędek A, et al. Propozycja procedury oceny przeciwpłytkowych właściwości preparatów polifenolowych pochodzenia roślinnego w badaniach in vitro. Postępy Fitoter. 2012; 1: 3–10.
  4. Görlinger K, Jambor C, Dirkmann D, et al. Platelet function analysis with point-of-care methods. Herz. 2008; 33(4): 297–305.
  5. Jámbor C, Weber CF, Gerhardt K, et al. Whole blood multiple electrode aggregometry is a reliable point-of-care test of aspirin-induced platelet dysfunction. Anesth Analg. 2009; 109(1): 25–31.
  6. Pakala R, Waksman R. Currently available methods for platelet function analysis: advantages and disadvantages. Cardiovasc Revasc Med. 2011; 12(5): 312–322.
  7. Paniccia R, Priora R, Liotta AA, et al. Platelet function tests: a comparative review. Vasc Health Risk Manag. 2015; 11: 133–148.
  8. Vidali M, Rolla R, Parrella M, et al. Role of the laboratory in monitoring patients receiving dual antiplatelet therapy. Int J Lab Hematol. 2012; 34(5): 484–494.
  9. Paniccia R, Antonucci E, Maggini N, et al. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol. 2009; 131(6): 834–842.
  10. Kozek-Langenecker SA, Ahmed AB, Afshari A, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2013; 30(6): 270–382.
  11. Rossaint R, Bouillon B, Cerny V, et al. Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: an updated European guideline. Crit Care. 2010; 14(2): R52.
  12. Kutcher ME, Redick BJ, McCreery RC, et al. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg. 2012; 73(1): 13–19.
  13. Brown LM, Call MS, Margaret Knudson M, et al. Trauma Outcomes Group. A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011; 71(2 Suppl 3): S337–S342.
  14. Solomon C, Traintinger S, Ziegler B, et al. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost. 2011; 106(2): 322–330.
  15. Jacoby RC, Owings JT, Holmes J, et al. Platelet activation and function after trauma. J Trauma. 2001; 51(4): 639–647.
  16. Rossaint R, Bouillon B, Cerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016; 20: 100.
  17. Hartmann M, Sucker C, Boehm O, et al. Effects of cardiac surgery on hemostasis. Transfus Med Rev. 2006; 20(3): 230–241.
  18. Solomon C, Hartmann J, Osthaus A, et al. Platelet concentrates transfusion in cardiac surgery in relation to preoperative point-of-care assessment of platelet adhesion and aggregation. Platelets. 2010; 21(3): 221–228.
  19. Ranucci M, Baryshnikova E, Soro G, et al. Surgical and Clinical Outcome Research (SCORE) Group. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg. 2011; 91(1): 123–129.
  20. Weber CF, Görlinger K, Meininger D, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012; 117(3): 531–547.
  21. Schulte am Esch J, Akyildiz A, Tustas RY, et al. ADP-dependent platelet function prior to and in the early course of pediatric liver transplantation and persisting thrombocytopenia are positively correlated with ischemia/reperfusion injury. Transpl Int. 2010; 23(7): 745–752.
  22. Bergmann L, Kienbaum P, Görlinger K, et al. Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid. Reg Anesth Pain Med. 2007; 32(4): 354–357.
  23. Hanke AA, Roberg K, Monaca E, et al. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate). Eur J Med Res. 2010; 15(5): 214–219.
  24. Rahe-Meyer N, Winterhalter M, Boden A, et al. Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand. 2009; 53(2): 168–175.
  25. Weber CF, Dietrich W, Spannagl M, et al. A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery. Anesth Analg. 2010; 110(3): 702–707.

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