open access

Vol 49, No 2 (2017)
Review articles
Published online: 2017-05-16
Submitted: 2017-02-12
Accepted: 2017-04-14
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Platelets in sepsis — are there any new aspects?

Małgorzata Lipinska-Gediga
DOI: 10.5603/AIT.a2017.0025
·
Pubmed: 28513821
·
Anaesthesiol Intensive Ther 2017;49(2):167-172.

open access

Vol 49, No 2 (2017)
Review articles
Published online: 2017-05-16
Submitted: 2017-02-12
Accepted: 2017-04-14

Abstract

Platelets display a number of properties besides the crucial function of repairing a damaged vascular endothelium and stopping bleeding. Platelets constitutively express molecules that are classically acknowledged to function in primary haemostasis. Platelets specialize in pro-inflammatory activities, and can secrete a large number of molecules, many of which display biological response modifier functions. Recently, platelets expressing receptors for infectious and possibly noninfectious danger signals were shown to be involved in pathophysiological reactions including an immune-inflammatory response. In sepsis, platelets play a key role in immunothrombosis, participate in the formation of NETs (neutrophil extracellular trap) resulting in the trapping and killing of pathogens and are one of the main factors influencing mortality.

Abstract

Platelets display a number of properties besides the crucial function of repairing a damaged vascular endothelium and stopping bleeding. Platelets constitutively express molecules that are classically acknowledged to function in primary haemostasis. Platelets specialize in pro-inflammatory activities, and can secrete a large number of molecules, many of which display biological response modifier functions. Recently, platelets expressing receptors for infectious and possibly noninfectious danger signals were shown to be involved in pathophysiological reactions including an immune-inflammatory response. In sepsis, platelets play a key role in immunothrombosis, participate in the formation of NETs (neutrophil extracellular trap) resulting in the trapping and killing of pathogens and are one of the main factors influencing mortality.

Get Citation

Keywords

sepsis, pathogens; sepsis, thrombocytes; NETs; receptors

About this article
Title

Platelets in sepsis — are there any new aspects?

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 49, No 2 (2017)

Pages

167-172

Published online

2017-05-16

DOI

10.5603/AIT.a2017.0025

Pubmed

28513821

Bibliographic record

Anaesthesiol Intensive Ther 2017;49(2):167-172.

Keywords

sepsis
pathogens
sepsis
thrombocytes
NETs
receptors

Authors

Małgorzata Lipinska-Gediga

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