open access

Vol 48, No 5 (2016)
Original and clinical articles
Published online: 2016-11-10
Submitted: 2016-07-23
Accepted: 2016-11-02
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Effect of preoperative intravenous oxycodone administration on sufentanil consumption after retroperitoneal laparoscopic nephrectomy

Jinguo Wang, Haichun Ma, Honglan Zhou, Yang Gao, Yaowen Fu, Na Wang
DOI: 10.5603/AIT.a2016.0052
·
Pubmed: 27834984
·
Anaesthesiol Intensive Ther 2016;48(5):300-304.

open access

Vol 48, No 5 (2016)
Original and clinical articles
Published online: 2016-11-10
Submitted: 2016-07-23
Accepted: 2016-11-02

Abstract

BACKGROUND: The aim of this study was to evaluate the efficacy of preoperative intravenous oxycodone administration on postoperative sufentanil consumption in patients undergoing retroperitoneal laparoscopic nephrectomy.

METHODS: Fifty patients scheduled for retroperitoneal laparoscopic nephrectomy were enrolled and randomly assigned to two groups — patients in Group O (n = 25) received intravenously 0.1 mg kg-1 oxycodone; while the patients in Group C (n = 25) received 0.1 mL kg-1 normal saline for 2 min, 10 min before the operation. All of the participants received intravenous sufentanil patient-controlled analgesia (PCA) after extubation, using a PCA device. The sufentanil consumption, rescue analgesia, Ramsay sedation scale (RSS) and visual analogue scale (VAS) scores at rest and during cough, the overall satisfaction and undesired events were all assessed.

RESULTS: Cumulative sufentanil consumption delivered by PCA was significantly lower in Group O at all time points. VAS scores at rest and during coughing at 1, 2, 4, 8 and 12 hours after extubation of the patient were significantly lower in Group O than in Group C. There were no significant differences between the two groups according to the number of patients administered tramadol, RSS and the incidence of side effects. The degree of patients’ satisfaction was higher in Group O.

CONCLUSION: Preoperative intravenous oxycodone can reduce postoperative cumulative sufentanil consumption and postoperative pain intensity without an increase in side effects.

Abstract

BACKGROUND: The aim of this study was to evaluate the efficacy of preoperative intravenous oxycodone administration on postoperative sufentanil consumption in patients undergoing retroperitoneal laparoscopic nephrectomy.

METHODS: Fifty patients scheduled for retroperitoneal laparoscopic nephrectomy were enrolled and randomly assigned to two groups — patients in Group O (n = 25) received intravenously 0.1 mg kg-1 oxycodone; while the patients in Group C (n = 25) received 0.1 mL kg-1 normal saline for 2 min, 10 min before the operation. All of the participants received intravenous sufentanil patient-controlled analgesia (PCA) after extubation, using a PCA device. The sufentanil consumption, rescue analgesia, Ramsay sedation scale (RSS) and visual analogue scale (VAS) scores at rest and during cough, the overall satisfaction and undesired events were all assessed.

RESULTS: Cumulative sufentanil consumption delivered by PCA was significantly lower in Group O at all time points. VAS scores at rest and during coughing at 1, 2, 4, 8 and 12 hours after extubation of the patient were significantly lower in Group O than in Group C. There were no significant differences between the two groups according to the number of patients administered tramadol, RSS and the incidence of side effects. The degree of patients’ satisfaction was higher in Group O.

CONCLUSION: Preoperative intravenous oxycodone can reduce postoperative cumulative sufentanil consumption and postoperative pain intensity without an increase in side effects.

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Keywords

opioids, oxycodone, sufentanil; postoperative pain, prophylaxis; postoperative pain, treatment, patient- -controlled analgesia; laparoscopic nephrectomy

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About this article
Title

Effect of preoperative intravenous oxycodone administration on sufentanil consumption after retroperitoneal laparoscopic nephrectomy

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 48, No 5 (2016)

Pages

300-304

Published online

2016-11-10

DOI

10.5603/AIT.a2016.0052

Pubmed

27834984

Bibliographic record

Anaesthesiol Intensive Ther 2016;48(5):300-304.

Keywords

opioids
oxycodone
sufentanil
postoperative pain
prophylaxis
postoperative pain
treatment
patient- -controlled analgesia
laparoscopic nephrectomy

Authors

Jinguo Wang
Haichun Ma
Honglan Zhou
Yang Gao
Yaowen Fu
Na Wang

References (9)
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