open access

Vol 48, No 3 (2016)
Original and clinical articles
Published online: 2016-06-20
Submitted: 2016-01-25
Accepted: 2016-05-01
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Risk factors of acute kidney injury requiring renal replacement therapy based on regional registry data

Piotr Czempik, Daniel Cieśla, Piotr Knapik, Łukasz J. Krzych
DOI: 10.5603/AIT.a2016.0033
·
Anaesthesiol Intensive Ther 2016;48(3):185-190.

open access

Vol 48, No 3 (2016)
Original and clinical articles
Published online: 2016-06-20
Submitted: 2016-01-25
Accepted: 2016-05-01

Abstract

BACKGROUND: Acute kidney injury (AKI) is a common problem in critically ill patients treated in the intensive care unit (ICU) and is associated with high mortality, particularly when renal replacement therapy (RRT) is required. Our aim was to investigate the risk factors for AKI requiring RRT (AKI-RRT).

METHODS: In our retrospective, multi-centre, observational study, we analysed 14,672 consecutive AKI-RRT patients hospitalized in ICUs in the Silesian Region (Poland) between October 2011 and December 2014. Demographic and clinical data were derived from the Silesian Registry of Anaesthesiology and Intensive Care Departments. Logistic regression was used to select final risk factors for AKI-RRT. The ROC method was used to analyse the value of clinical parameters to predict the risk of AKI-RRT.

RESULTS: Of a total of 14,672 patients, 1,234 (8.4%) developed AKI requiring RRT. Overall 59% of patients were males and the median age in the group was 66 (IQR 55−76) years. There were 16 variables that modified the risk of AKI-RRT. The AUROC for the test scored 0.845 (95% CI: 0.84−0.85; P < 0.0001).

CONCLUSION: We found multiple factors that modified the risk of AKI requiring RRT. Chronic kidney disease (CKD) and cardiogenic shock increased, whereas neurological disorders decreased the risk. Measures directed towards AKI prevention should be aimed specifically at patients with cardiological disorders and CKD.

Abstract

BACKGROUND: Acute kidney injury (AKI) is a common problem in critically ill patients treated in the intensive care unit (ICU) and is associated with high mortality, particularly when renal replacement therapy (RRT) is required. Our aim was to investigate the risk factors for AKI requiring RRT (AKI-RRT).

METHODS: In our retrospective, multi-centre, observational study, we analysed 14,672 consecutive AKI-RRT patients hospitalized in ICUs in the Silesian Region (Poland) between October 2011 and December 2014. Demographic and clinical data were derived from the Silesian Registry of Anaesthesiology and Intensive Care Departments. Logistic regression was used to select final risk factors for AKI-RRT. The ROC method was used to analyse the value of clinical parameters to predict the risk of AKI-RRT.

RESULTS: Of a total of 14,672 patients, 1,234 (8.4%) developed AKI requiring RRT. Overall 59% of patients were males and the median age in the group was 66 (IQR 55−76) years. There were 16 variables that modified the risk of AKI-RRT. The AUROC for the test scored 0.845 (95% CI: 0.84−0.85; P < 0.0001).

CONCLUSION: We found multiple factors that modified the risk of AKI requiring RRT. Chronic kidney disease (CKD) and cardiogenic shock increased, whereas neurological disorders decreased the risk. Measures directed towards AKI prevention should be aimed specifically at patients with cardiological disorders and CKD.

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Keywords

acute kidney injury; risk factors; renal replacement therapy; intensive care unit

About this article
Title

Risk factors of acute kidney injury requiring renal replacement therapy based on regional registry data

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 48, No 3 (2016)

Pages

185-190

Published online

2016-06-20

DOI

10.5603/AIT.a2016.0033

Bibliographic record

Anaesthesiol Intensive Ther 2016;48(3):185-190.

Keywords

acute kidney injury
risk factors
renal replacement therapy
intensive care unit

Authors

Piotr Czempik
Daniel Cieśla
Piotr Knapik
Łukasz J. Krzych

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