open access

Vol 48, No 3 (2016)
Original and clinical articles
Published online: 2016-03-23
Submitted: 2015-10-07
Accepted: 2016-03-09
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Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients

Katarzyna Talaga, Paweł Krzyściak, Małgorzata Bulanda
DOI: 10.5603/AIT.a2016.0021
·
Anaesthesiol Intensive Ther 2016;48(3):166-170.

open access

Vol 48, No 3 (2016)
Original and clinical articles
Published online: 2016-03-23
Submitted: 2015-10-07
Accepted: 2016-03-09

Abstract

BACKGROUND: Infections caused by Acinetobacter baumannii are difficult to cure due to the acquisition of resistance by these bacteria and lead to an increase in the general costs of hospitalization. The aim of this study was to determine tigecycline susceptibility of Acinetobacter baumannii strains isolated from intensive care unit and non-intensive care unit patients with skin and soft tissue infections.

METHODS: MICs were tested by Etest among 70 Acinetobacter baumannii isolates.

RESULTS: The MIC range was from 0.5 to 8.0 mg L-1. For ESBL-producing Acinetobacter baumannii, as well as for strains without carbapenemases, the highest MIC to tigecycline value was 8.0 mg L-1. For AmpC-producing Acinetobacter baumannii, the highest MIC to tigecycline value was 6.0 mg L-1 and, for MBL-producing strains, 2.0 mg L-1.

CONCLUSIONS: The majority of Acinetobacter baumannii strains isolated from ICU and non-ICU patients demonstrated high values of MIC range, MIC50 and MIC90 to tigecycline.

Abstract

BACKGROUND: Infections caused by Acinetobacter baumannii are difficult to cure due to the acquisition of resistance by these bacteria and lead to an increase in the general costs of hospitalization. The aim of this study was to determine tigecycline susceptibility of Acinetobacter baumannii strains isolated from intensive care unit and non-intensive care unit patients with skin and soft tissue infections.

METHODS: MICs were tested by Etest among 70 Acinetobacter baumannii isolates.

RESULTS: The MIC range was from 0.5 to 8.0 mg L-1. For ESBL-producing Acinetobacter baumannii, as well as for strains without carbapenemases, the highest MIC to tigecycline value was 8.0 mg L-1. For AmpC-producing Acinetobacter baumannii, the highest MIC to tigecycline value was 6.0 mg L-1 and, for MBL-producing strains, 2.0 mg L-1.

CONCLUSIONS: The majority of Acinetobacter baumannii strains isolated from ICU and non-ICU patients demonstrated high values of MIC range, MIC50 and MIC90 to tigecycline.

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Keywords

Acinetobacter baumannii; antibiotics, tigecycline, susceptibility; intensive care unit, infections

About this article
Title

Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 48, No 3 (2016)

Pages

166-170

Published online

2016-03-23

DOI

10.5603/AIT.a2016.0021

Bibliographic record

Anaesthesiol Intensive Ther 2016;48(3):166-170.

Keywords

Acinetobacter baumannii
antibiotics
tigecycline
susceptibility
intensive care unit
infections

Authors

Katarzyna Talaga
Paweł Krzyściak
Małgorzata Bulanda

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