open access

Vol 47, No 2 (2015)
Original and clinical articles
Submitted: 2015-04-24
Accepted: 2015-04-24
Get Citation

Balanced hydroxyethyl starch solution and hyperglycaemia in non diabetics — a prospective, randomized and controlled study

Soumya Sankar Nath, Sundeep T. Pawar, Farrukh Ansari, Roy Debashis
DOI: 10.5603/AIT.2015.0014
·
Anaesthesiol Intensive Ther 2015;47(2):134-137.

open access

Vol 47, No 2 (2015)
Original and clinical articles
Submitted: 2015-04-24
Accepted: 2015-04-24

Abstract

Background: There are very few studies that have examined the effect of hydroxyethyl starch (HES) solutions on blood glucose level. The study was aimed to compare the effects on blood glucose levels in patients undergoing lower limb surgeries under neuraxial block, receiving HES with those receiving 0.9% saline.

Patients and methods: 160 non-diabetic ASA I or II patients, aged between 18−65 years were selected for the trial. Patients were divided into two groups; Group C (n = 80, patients received only 0.9% saline for preloading and maintenance until six hours of the end of preloading) and Group T (n = 80, patients received Tetraspan 10 mL kg-1, for preloading and 0.9% saline for maintenance until six hours from the end of preloading). Blood glucose was recorded prior to the start of preloading and repeated at two, four and six hours after the end of HES infusion or the preloading dose of 0.9% saline.

Results: The following blood glucose levels were comparable at all times; fasting/baseline (85.3 ± 19.2 mg dL-1 in group C and 95.4 ± 17.3 mg dL-1 in group T); increase in blood glucose concentration at 2 hours (6.44 ± 20.59 mg dL-1 in group C and 10.8 ± 18.1 mg dL-1 in group T); 4 hours (4.1 ± 12.1 mg dL-1 in group C and 3.5 ± 11.8 mg dL-1 in group T); and at 6 hours (2.9 ± 13.4 mg dL-1 in group C and 3.5 ± 10.6 mg dL-1 in group T).

Conclusion: A balanced HES solution administered intravenously did not cause an increase in blood glucose concentrations compared to those who received 0.9% saline.

Abstract

Background: There are very few studies that have examined the effect of hydroxyethyl starch (HES) solutions on blood glucose level. The study was aimed to compare the effects on blood glucose levels in patients undergoing lower limb surgeries under neuraxial block, receiving HES with those receiving 0.9% saline.

Patients and methods: 160 non-diabetic ASA I or II patients, aged between 18−65 years were selected for the trial. Patients were divided into two groups; Group C (n = 80, patients received only 0.9% saline for preloading and maintenance until six hours of the end of preloading) and Group T (n = 80, patients received Tetraspan 10 mL kg-1, for preloading and 0.9% saline for maintenance until six hours from the end of preloading). Blood glucose was recorded prior to the start of preloading and repeated at two, four and six hours after the end of HES infusion or the preloading dose of 0.9% saline.

Results: The following blood glucose levels were comparable at all times; fasting/baseline (85.3 ± 19.2 mg dL-1 in group C and 95.4 ± 17.3 mg dL-1 in group T); increase in blood glucose concentration at 2 hours (6.44 ± 20.59 mg dL-1 in group C and 10.8 ± 18.1 mg dL-1 in group T); 4 hours (4.1 ± 12.1 mg dL-1 in group C and 3.5 ± 11.8 mg dL-1 in group T); and at 6 hours (2.9 ± 13.4 mg dL-1 in group C and 3.5 ± 10.6 mg dL-1 in group T).

Conclusion: A balanced HES solution administered intravenously did not cause an increase in blood glucose concentrations compared to those who received 0.9% saline.

Get Citation

Keywords

colloids, balanced hydroxyethyl starch, side effects, blood glucose

About this article
Title

Balanced hydroxyethyl starch solution and hyperglycaemia in non diabetics — a prospective, randomized and controlled study

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 47, No 2 (2015)

Pages

134-137

DOI

10.5603/AIT.2015.0014

Bibliographic record

Anaesthesiol Intensive Ther 2015;47(2):134-137.

Keywords

colloids
balanced hydroxyethyl starch
side effects
blood glucose

Authors

Soumya Sankar Nath
Sundeep T. Pawar
Farrukh Ansari
Roy Debashis

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

VM Media sp. z o.o. VM Group sp.k., Grupa Via Medica, Świętokrzyska 73 St., 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl