open access

Vol 46, No 4 (2014 Sep-Oct)
Original and clinical articles
Submitted: 2014-10-07
Accepted: 2014-10-07
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The effect of bispectral index monitoring on anaesthetic requirements in target-controlled infusion for lumbar microdiscectomy

Zbigniew Karwacki, Seweryn Niewiadomski, Marta Rzaska, Małgorzata Witkowska
DOI: 10.5603/AIT.2014.0046
·
Anaesthesiol Intensive Ther 2014;46(4):284-288.

open access

Vol 46, No 4 (2014 Sep-Oct)
Original and clinical articles
Submitted: 2014-10-07
Accepted: 2014-10-07

Abstract

Background: Target-controlled infusion (TCI) is used to maintain the desired concentration of a hypnotic drug in the plasma and brain. However, pharmacodynamic variability can cause problems with maintaining the adequate level of anaesthesia. The bispectral index (BIS) is one of only a few parameters that allow an assessment of the depth of anaesthesia. In the present study, we attempted to determine the optimal dosages of drugs used for total intravenous anaesthesia with TCI based on BIS-guided monitoring of depth of anaesthesia.

Methods: The study was conducted in 60 ASA I patients undergoing elective surgery due to lumbar discopathy. The participants were divided into two groups of 30 individuals. The patients were premedicated with 15 mg oral midazolam. Group I was the control group; group II received BIS monitoring. Anaesthesia was induced with TCI propofol (4 mg mL-1), fentanyl (2 mg kg-1) and vecuronium (0.12 mg kg-1) and maintained with TCI propofol, continuous infusion of vecuronium (0.03 mg kg-1 h-1) and fractionated doses of fentanyl. ECG, HR, MAP, SaO2, ETCO2, and the degree of neuromuscular blockade were monitored, specifically at the following time points: T1 — before induction, T2 — after induction, T3 — after intubation, T4 — after positioning of the patient, T5-T13 — every 5 min during surgery, T14 — on completion of surgery, T15 — before extubation, T16 — after extubation.

Results: The study groups were comparable in terms of age, body weight, duration of anaesthesia and recovery time. The haemodynamic parameters, such as HR and MAP, did not differ significantly between the groups. In both groups, changes in the mean MAP values were observed between T1 and T2, T2 and T3, T3 and T4 as well as T14and T15. The total dose of fentanyl and the doses of propofol were lower in the group that received BIS monitoring.

Conclusion: BIS monitoring reduces the doses of opioids and hypnotics used during total intravenous anaesthesia by TCI.

Abstract

Background: Target-controlled infusion (TCI) is used to maintain the desired concentration of a hypnotic drug in the plasma and brain. However, pharmacodynamic variability can cause problems with maintaining the adequate level of anaesthesia. The bispectral index (BIS) is one of only a few parameters that allow an assessment of the depth of anaesthesia. In the present study, we attempted to determine the optimal dosages of drugs used for total intravenous anaesthesia with TCI based on BIS-guided monitoring of depth of anaesthesia.

Methods: The study was conducted in 60 ASA I patients undergoing elective surgery due to lumbar discopathy. The participants were divided into two groups of 30 individuals. The patients were premedicated with 15 mg oral midazolam. Group I was the control group; group II received BIS monitoring. Anaesthesia was induced with TCI propofol (4 mg mL-1), fentanyl (2 mg kg-1) and vecuronium (0.12 mg kg-1) and maintained with TCI propofol, continuous infusion of vecuronium (0.03 mg kg-1 h-1) and fractionated doses of fentanyl. ECG, HR, MAP, SaO2, ETCO2, and the degree of neuromuscular blockade were monitored, specifically at the following time points: T1 — before induction, T2 — after induction, T3 — after intubation, T4 — after positioning of the patient, T5-T13 — every 5 min during surgery, T14 — on completion of surgery, T15 — before extubation, T16 — after extubation.

Results: The study groups were comparable in terms of age, body weight, duration of anaesthesia and recovery time. The haemodynamic parameters, such as HR and MAP, did not differ significantly between the groups. In both groups, changes in the mean MAP values were observed between T1 and T2, T2 and T3, T3 and T4 as well as T14and T15. The total dose of fentanyl and the doses of propofol were lower in the group that received BIS monitoring.

Conclusion: BIS monitoring reduces the doses of opioids and hypnotics used during total intravenous anaesthesia by TCI.

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Keywords

general anaesthesia, target controlled infusion; anaesthetics, intravenous, propofol

About this article
Title

The effect of bispectral index monitoring on anaesthetic requirements in target-controlled infusion for lumbar microdiscectomy

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 46, No 4 (2014 Sep-Oct)

Pages

284-288

DOI

10.5603/AIT.2014.0046

Bibliographic record

Anaesthesiol Intensive Ther 2014;46(4):284-288.

Keywords

general anaesthesia
target controlled infusion
anaesthetics
intravenous
propofol

Authors

Zbigniew Karwacki
Seweryn Niewiadomski
Marta Rzaska
Małgorzata Witkowska

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