open access

Vol 47, No 4 (2015)
Review articles
Published online: 2015-06-03
Submitted: 2014-09-18
Accepted: 2014-12-18
Get Citation

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Ovidiu Horea Bedreag, Alexandru Florin Rogobete, Mirela Sarandan, Alina Carmen Cradigati, Marius Papurica, Maria Corina Dumbuleu, Alexandru Mihai Chira, Oana Maria Rosu, Dorel Sandesc
DOI: 10.5603/AIT.a2015.0030
·
Anaesthesiol Intensive Ther 2015;47(4):351-359.

open access

Vol 47, No 4 (2015)
Review articles
Published online: 2015-06-03
Submitted: 2014-09-18
Accepted: 2014-12-18

Abstract

Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

Abstract

Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

Get Citation

Keywords

lung injury, inflammation; oxidative stress, antioxidant therapy; multiple trauma; critically ill patient

About this article
Title

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 47, No 4 (2015)

Pages

351-359

Published online

2015-06-03

DOI

10.5603/AIT.a2015.0030

Bibliographic record

Anaesthesiol Intensive Ther 2015;47(4):351-359.

Keywords

lung injury
inflammation
oxidative stress
antioxidant therapy
multiple trauma
critically ill patient

Authors

Ovidiu Horea Bedreag
Alexandru Florin Rogobete
Mirela Sarandan
Alina Carmen Cradigati
Marius Papurica
Maria Corina Dumbuleu
Alexandru Mihai Chira
Oana Maria Rosu
Dorel Sandesc

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