open access

Vol 44, No 1 (2012 Jan-Mar)
Review articles
Published online: 2012-03-30
Submitted: 2012-03-30
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Sufentanil in anaesthesiology and intensive therapy

Dariusz Maciejewski
Anaesthesiol Intensive Ther 2012;44(1):35-41.

open access

Vol 44, No 1 (2012 Jan-Mar)
Review articles
Published online: 2012-03-30
Submitted: 2012-03-30

Abstract

Sufentanil, a potent α-1 agonistic opioid, was synthesized in mid-1970s. It was introduced into clinical practice ten years later, gaining some popularity over the last twenty years. A piperidine derivative, sufentanil has been reported to be 6-10 times more potent than fentanyl, depending on the route of administration; it has been registered for intravenous, epidural and subarachnoid administration. Its reported off-label use has included intra-articular and intranasal administration; moreover, it has been applied as an adjunct in peripheral blocks. In the review, contemporary uses of sufentanil, together with detailed pharmacokinetics and pharmacodynamics are presented. The author concludes that the limited side effects of sufentanil, together with its attractive pharmacokinetic profile, should promote its wider use in clinical practice.

Abstract

Sufentanil, a potent α-1 agonistic opioid, was synthesized in mid-1970s. It was introduced into clinical practice ten years later, gaining some popularity over the last twenty years. A piperidine derivative, sufentanil has been reported to be 6-10 times more potent than fentanyl, depending on the route of administration; it has been registered for intravenous, epidural and subarachnoid administration. Its reported off-label use has included intra-articular and intranasal administration; moreover, it has been applied as an adjunct in peripheral blocks. In the review, contemporary uses of sufentanil, together with detailed pharmacokinetics and pharmacodynamics are presented. The author concludes that the limited side effects of sufentanil, together with its attractive pharmacokinetic profile, should promote its wider use in clinical practice.

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Keywords

analgesic, opioid, fentanyl; analgesic, opioid, sufentanil; pharmacology, sufentanil

About this article
Title

Sufentanil in anaesthesiology and intensive therapy

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 44, No 1 (2012 Jan-Mar)

Pages

35-41

Published online

2012-03-30

Bibliographic record

Anaesthesiol Intensive Ther 2012;44(1):35-41.

Keywords

analgesic
opioid
fentanyl
analgesic
opioid
sufentanil
pharmacology
sufentanil

Authors

Dariusz Maciejewski

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