open access

Vol 45, No 1 (2013 Jan-Mar)
Original and clinical articles
Published online: 2013-03-19
Submitted: 2013-03-19
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The impact of colloid infusion prior to spinal anaesthesia for caesarean section on the condition of a newborn — a comparison of balanced and unbalanced hydroxyethyl starch 130/0.4

Andrzej Marciniak, Maria Wujtewicz, Radosław Owczuk
DOI: 10.5603/AIT.2013.0003
·
Anaesthesiol Intensive Ther 2013;45(1):14-19.

open access

Vol 45, No 1 (2013 Jan-Mar)
Original and clinical articles
Published online: 2013-03-19
Submitted: 2013-03-19

Abstract

BACKGROUND: Fluid therapy is the most commonly used treatment to prevent hypotension associated with spinal anaesthesia. The aim of this study was to test the hypothesis that a balanced solution of 6% hydroxyethyl starch will have a more beneficial impact on the condition of newborns at birth than an unbalanced 6% solution of HES.

METHODS: The study participants included 51 healthy parturients undergoing elective caesarean section with spinal anaesthesia. Patients received a transfusion of 500 mL of unbalanced 6% HES (Voluven) or balanced 6% HES (Tetraspan) prior to anaesthesia. The condition of the newborn was assessed using the Apgar score, and the acid-base balances of venous and arterial umbilical cord blood were also measured.

RESULTS: The incidence of hypotension after spinal anaesthesia was 80% in Group A and 76.9% in Group B ( P = 1.0). There were no differences between the two groups in the total doses of ephedrine and no differences between treatment groups in Apgar scores. Also, no differences in acid-base balance parameters (pH, H+, pCO2, pO2, HCO3-, BE) were found.

CONCLUSION: A balanced 6% solution of hydroxyethyl starch (HES 130/0.42) did not significantly influence the condition of the newborns at birth or the acid-base and electrolyte concentration of newborns compared to an unbalanced solution of 6% hydroxyethyl starch (HES 130/0.4).

Abstract

BACKGROUND: Fluid therapy is the most commonly used treatment to prevent hypotension associated with spinal anaesthesia. The aim of this study was to test the hypothesis that a balanced solution of 6% hydroxyethyl starch will have a more beneficial impact on the condition of newborns at birth than an unbalanced 6% solution of HES.

METHODS: The study participants included 51 healthy parturients undergoing elective caesarean section with spinal anaesthesia. Patients received a transfusion of 500 mL of unbalanced 6% HES (Voluven) or balanced 6% HES (Tetraspan) prior to anaesthesia. The condition of the newborn was assessed using the Apgar score, and the acid-base balances of venous and arterial umbilical cord blood were also measured.

RESULTS: The incidence of hypotension after spinal anaesthesia was 80% in Group A and 76.9% in Group B ( P = 1.0). There were no differences between the two groups in the total doses of ephedrine and no differences between treatment groups in Apgar scores. Also, no differences in acid-base balance parameters (pH, H+, pCO2, pO2, HCO3-, BE) were found.

CONCLUSION: A balanced 6% solution of hydroxyethyl starch (HES 130/0.42) did not significantly influence the condition of the newborns at birth or the acid-base and electrolyte concentration of newborns compared to an unbalanced solution of 6% hydroxyethyl starch (HES 130/0.4).

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Keywords

caesarean section, spinal anaesthesia; caesarean section, newborn condition; spinal anaesthesia, hypotension; balanced colloid solutions, hydroxyethyl starch

About this article
Title

The impact of colloid infusion prior to spinal anaesthesia for caesarean section on the condition of a newborn — a comparison of balanced and unbalanced hydroxyethyl starch 130/0.4

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 45, No 1 (2013 Jan-Mar)

Pages

14-19

Published online

2013-03-19

DOI

10.5603/AIT.2013.0003

Bibliographic record

Anaesthesiol Intensive Ther 2013;45(1):14-19.

Keywords

caesarean section
spinal anaesthesia
caesarean section
newborn condition
spinal anaesthesia
hypotension
balanced colloid solutions
hydroxyethyl starch

Authors

Andrzej Marciniak
Maria Wujtewicz
Radosław Owczuk

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