open access

Vol 45, No 1 (2013 Jan-Mar)
Original and clinical articles
Published online: 2013-03-19
Submitted: 2013-03-19
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Complications in patients treated with plasmapheresis in the intensive care unit

Wojciech Szczeklik, Katarzyna Wawrzycka, Anna Włudarczyk, Aurelia Sega, Ilona Nowak, Bożena Seczyńska, Izabela Fajfer, Krzysztof Zając, Wiesław Królikowski, Maria Kózka
DOI: 10.5603/AIT.2013.0002
·
Anaesthesiol Intensive Ther 2013;45(1):7-13.

open access

Vol 45, No 1 (2013 Jan-Mar)
Original and clinical articles
Published online: 2013-03-19
Submitted: 2013-03-19

Abstract

BACKGROUND: Plasmapheresis is one of the methods of extracorporeal blood purification involving the removal of inflammatory mediators and antibodies. The procedure is used in a variety of ailments, including autoimmune diseases. The aim of the present study was to analyse the incidence of plasmapheresis-related complications in patients treated in the intensive care unit (ICU).

METHODS: The analysis involved 370 plasmapheresis procedures in 54 patients. The data were collected from patients` medical records, including procedure protocols.

RESULTS: The most common diseases treated with plasmapheresis included: myasthenia gravis (33.3%), Guillain-Barré syndrome (14%), Lyell’s syndrome (9.3%), systemic lupus erythematosus (7.4%), and thrombotic thromcytopenic purpura (7.4%). The adverse side effects observed most frequently during plasma filtration were decreases in arterial blood pressure (8.4% of all procedures), arrhythmias (3.5%), sensations of cold with temporarily elevated temperature and paresthesias (1.1%, each). In most cases, the symptoms were mild and transient. Severe and life-threatening episodes, i.e. shock, drops in arterial blood pressure requiring catecholamines administration, persistent arrhythmias and haemolysis, developed in 2.16% of procedures.

CONCLUSIONS: Plasmapheresis can be considered a relatively safe method of treatment of ICU patients. Continuous observation and proper monitoring of patients provided by highly trained medical personnel are essential for its safety.

Abstract

BACKGROUND: Plasmapheresis is one of the methods of extracorporeal blood purification involving the removal of inflammatory mediators and antibodies. The procedure is used in a variety of ailments, including autoimmune diseases. The aim of the present study was to analyse the incidence of plasmapheresis-related complications in patients treated in the intensive care unit (ICU).

METHODS: The analysis involved 370 plasmapheresis procedures in 54 patients. The data were collected from patients` medical records, including procedure protocols.

RESULTS: The most common diseases treated with plasmapheresis included: myasthenia gravis (33.3%), Guillain-Barré syndrome (14%), Lyell’s syndrome (9.3%), systemic lupus erythematosus (7.4%), and thrombotic thromcytopenic purpura (7.4%). The adverse side effects observed most frequently during plasma filtration were decreases in arterial blood pressure (8.4% of all procedures), arrhythmias (3.5%), sensations of cold with temporarily elevated temperature and paresthesias (1.1%, each). In most cases, the symptoms were mild and transient. Severe and life-threatening episodes, i.e. shock, drops in arterial blood pressure requiring catecholamines administration, persistent arrhythmias and haemolysis, developed in 2.16% of procedures.

CONCLUSIONS: Plasmapheresis can be considered a relatively safe method of treatment of ICU patients. Continuous observation and proper monitoring of patients provided by highly trained medical personnel are essential for its safety.

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Keywords

plasmapheresis, complications, intensive care

About this article
Title

Complications in patients treated with plasmapheresis in the intensive care unit

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 45, No 1 (2013 Jan-Mar)

Pages

7-13

Published online

2013-03-19

DOI

10.5603/AIT.2013.0002

Bibliographic record

Anaesthesiol Intensive Ther 2013;45(1):7-13.

Keywords

plasmapheresis
complications
intensive care

Authors

Wojciech Szczeklik
Katarzyna Wawrzycka
Anna Włudarczyk
Aurelia Sega
Ilona Nowak
Bożena Seczyńska
Izabela Fajfer
Krzysztof Zając
Wiesław Królikowski
Maria Kózka

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