open access

Vol 44, No 4 (2012 Oct-Dec)
Review articles
Published online: 2013-01-04
Submitted: 2013-01-07
Accepted: 2013-01-07
Get Citation

Molecular basics of sepsis developement

Monika Jedynak, Andrzej Siemiątkowski, Karolina Rygasiewicz
Anaesthesiol Intensive Ther 2012;44(4):248-252.

open access

Vol 44, No 4 (2012 Oct-Dec)
Review articles
Published online: 2013-01-04
Submitted: 2013-01-07
Accepted: 2013-01-07

Abstract

Bacterial infections and sepsis remain major causes of morbidity and mortality in intensive care units. The normal host response to infection is a complex process that serves to localise and control the invasion of microbes and to repair injured tissue. Local inflammatory processes are regulated through the production of cytokines by macrophages. In some cases, mediator release exceeds the boundaries of the local environment and results in the development of sepsis. It is well known that the innate immune system plays a crucial role in preventing microbial invasion. The human innate immune system consists of genetically programmed defence mechanisms that are directed against molecular components found only in microorganisms. Understanding the complexity of early response to infection with respect to innate immune response is required for the future development of drugs that will effectively control infectious diseases.

Abstract

Bacterial infections and sepsis remain major causes of morbidity and mortality in intensive care units. The normal host response to infection is a complex process that serves to localise and control the invasion of microbes and to repair injured tissue. Local inflammatory processes are regulated through the production of cytokines by macrophages. In some cases, mediator release exceeds the boundaries of the local environment and results in the development of sepsis. It is well known that the innate immune system plays a crucial role in preventing microbial invasion. The human innate immune system consists of genetically programmed defence mechanisms that are directed against molecular components found only in microorganisms. Understanding the complexity of early response to infection with respect to innate immune response is required for the future development of drugs that will effectively control infectious diseases.

Get Citation

Keywords

inflammation; innate immune response; inflammation; innate immune response; sepsis

About this article
Title

Molecular basics of sepsis developement

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 44, No 4 (2012 Oct-Dec)

Pages

248-252

Published online

2013-01-04

Bibliographic record

Anaesthesiol Intensive Ther 2012;44(4):248-252.

Keywords

inflammation
innate immune response
inflammation
innate immune response
sepsis

Authors

Monika Jedynak
Andrzej Siemiątkowski
Karolina Rygasiewicz

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

VM Media sp. z o.o. VM Group sp.k., Grupa Via Medica, Świętokrzyska 73 St., 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl