open access

Vol 44, No 2 (2012 Apr-Jun)
Original and clinical articles
Published online: 2012-08-08
Submitted: 2012-07-05
Accepted: 2012-07-05
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Effect on cognition of galanthamine administered for neuromuscular block reversal in octogenarians undergoing cataract surgery

Dimitri Cozanitis, Mirja Keinonen, Eeva-Lisa Maunuksela
Anaesthesiol Intensive Ther 2012;44(2):76-80.

open access

Vol 44, No 2 (2012 Apr-Jun)
Original and clinical articles
Published online: 2012-08-08
Submitted: 2012-07-05
Accepted: 2012-07-05

Abstract

BACKGROUND: The purpose of the study was to determine the possible effect of the cholinesterase inhibitor, galanthamine, on cognition when administered to antagonise neuromuscular blockade after anaesthesia.

METHODS: The Wechsler Memory Scale was used to assess cognition before and after cataract surgery, carried out under general anaesthesia, in forty-five octogenarian patients. At the end of the operation, in order to reverse residual neuromuscular blockade, patients were randomly assigned to receive either galanthamine, acting on central and peripheral receptors, or neostigmine — a drug without central activity.

RESULTS: The differences between the Wechsler Memory Scale scores obtained from both groups were not statistically significant; however, patients who received galanthamine experienced more side effects (e.g. nausea, vomiting, dysphoria) and had lower scores in memory tests performed immediately after surgery. Reduction of galanthamine doses did not improve the situation.

CONCLUSIONS: In octogenarians, impaired organ function as well as changes in body composition, are factors which affect the pharmacodynamics and pharmacokinetics of dru

Abstract

BACKGROUND: The purpose of the study was to determine the possible effect of the cholinesterase inhibitor, galanthamine, on cognition when administered to antagonise neuromuscular blockade after anaesthesia.

METHODS: The Wechsler Memory Scale was used to assess cognition before and after cataract surgery, carried out under general anaesthesia, in forty-five octogenarian patients. At the end of the operation, in order to reverse residual neuromuscular blockade, patients were randomly assigned to receive either galanthamine, acting on central and peripheral receptors, or neostigmine — a drug without central activity.

RESULTS: The differences between the Wechsler Memory Scale scores obtained from both groups were not statistically significant; however, patients who received galanthamine experienced more side effects (e.g. nausea, vomiting, dysphoria) and had lower scores in memory tests performed immediately after surgery. Reduction of galanthamine doses did not improve the situation.

CONCLUSIONS: In octogenarians, impaired organ function as well as changes in body composition, are factors which affect the pharmacodynamics and pharmacokinetics of dru

Get Citation

Keywords

neuromuscular blockade, reversal, galanthamine x neuromuscular blockade, reversal, neostigmine x galantamine, side effects

About this article
Title

Effect on cognition of galanthamine administered for neuromuscular block reversal in octogenarians undergoing cataract surgery

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 44, No 2 (2012 Apr-Jun)

Pages

76-80

Published online

2012-08-08

Bibliographic record

Anaesthesiol Intensive Ther 2012;44(2):76-80.

Keywords

neuromuscular blockade
reversal
galanthamine x neuromuscular blockade
reversal
neostigmine x galantamine
side effects

Authors

Dimitri Cozanitis
Mirja Keinonen
Eeva-Lisa Maunuksela

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