open access

Vol 89, No 4 (2021)
Case report
Submitted: 2020-11-16
Accepted: 2021-03-21
Published online: 2021-07-15
Get Citation

Probe-based confocal laser endomicroscopy in COVID-19

Igor Vladimirovich Vasilev1, Igor Sergeevich Mamenko1, Anna Valerievna Makarova1, Olga Pavlovna Sokolova1, Vladimir Fedorovich Lee1, Mahmud Mustafa Mortada1, Tatiana Alexandrovna Novickaya12, Piotr Kazimirovich Yablonskii12
DOI: 10.5603/ARM.a2021.0067
·
Pubmed: 34269405
·
Adv Respir Med 2021;89(4):456-459.
Affiliations
  1. Saint-Petersburg State Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  2. Saint-Petersburg State University, Medical Faculty, Saint-Petersburg, Russian Federation

open access

Vol 89, No 4 (2021)
CASE REPORTS
Submitted: 2020-11-16
Accepted: 2021-03-21
Published online: 2021-07-15

Abstract

Probe-based confocal laser endomicroscopy (pCLE) is a method that produces microscopic imaging of a lung tissue during bronchoscopy. We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID-19 was confirmed by PCR analyses of lavage fluid and transbrohial biopsy. The pCLE image shows density of alveolar thickened fibres, disorganization of elastin network, and multiple large drops of intraalveolar secretions. As far as we know, this is the first pCLE image discribed in patient with COVID-19 at that moment.

Abstract

Probe-based confocal laser endomicroscopy (pCLE) is a method that produces microscopic imaging of a lung tissue during bronchoscopy. We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID-19 was confirmed by PCR analyses of lavage fluid and transbrohial biopsy. The pCLE image shows density of alveolar thickened fibres, disorganization of elastin network, and multiple large drops of intraalveolar secretions. As far as we know, this is the first pCLE image discribed in patient with COVID-19 at that moment.

Get Citation

Keywords

confocal laser endomicroscopy; optical biopsy; COVID-19; SARS-CoV-2

About this article
Title

Probe-based confocal laser endomicroscopy in COVID-19

Journal

Advances in Respiratory Medicine

Issue

Vol 89, No 4 (2021)

Article type

Case report

Pages

456-459

Published online

2021-07-15

DOI

10.5603/ARM.a2021.0067

Pubmed

34269405

Bibliographic record

Adv Respir Med 2021;89(4):456-459.

Keywords

confocal laser endomicroscopy
optical biopsy
COVID-19
SARS-CoV-2

Authors

Igor Vladimirovich Vasilev
Igor Sergeevich Mamenko
Anna Valerievna Makarova
Olga Pavlovna Sokolova
Vladimir Fedorovich Lee
Mahmud Mustafa Mortada
Tatiana Alexandrovna Novickaya
Piotr Kazimirovich Yablonskii

References (10)
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  2. Guan WJ, Ni ZY, Hu Y, et al. China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382(18): 1708–1720.
  3. Bhimraj A, Morgan RL, Shumaker AH, et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. Clin Infect Dis. 2020 [Epub ahead of print].
  4. Thiberville L, Moreno-Swirc S, Vercauteren T, et al. In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy. Care Med. 2007; 175(1): 22–31.
  5. Hassan T, Thiberville L, Hermant C, et al. Assessing the feasibility of confocal laser endomicroscopy in solitary pulmonary nodules for different part of the lungs, using either 0.6 or 1.4 mm probes. PLoS One. 2017; 12(12): e0189846.
  6. Salaün M, Guisier F, Dominique S, et al. In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT. Respirology. 2019; 24(8): 783–791.
  7. Ora J, Puxeddu E, Cavalli F, et al. Does bronchoscopy help the diagnosis in COVID-19 infection? Eur Respir J. 2020; 56(2): 2001619.
  8. Yang Y, Yang M, Shen C, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv. 2020.
  9. Lentz R, Colt H. Summarizing societal guidelines regarding bronchoscopy during theCOVID‐19 pandemic. Respirology. 2020; 25(6): 574–577.
  10. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4): 420–422.

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