open access
Vitamin D status of severe COPD patients with chronic respiratory failure
open access
Abstract
Introduction: The aim of the study was to measure the concentrations of vitamin D in serum of COPD patients with chronic respiratory
failure in comparison to healthy control group. The correlation between the levels of vitamin D in serum and the selected
clinical, spirometric and blood gas parameters was the additional aim of the study.
Material and methods: The study included 61 patients with diagnosed COPD in stadium of chronic respiratory failure (45 men
and 16 women) and 37 healthy controls (19 men and 18 women). The following procedure were performed in all studied subjects:
detailed history (especially: daily activity, diet, tobacco and alcohol use), post-bronchodilator spirometry, assessment of 25(OH)D
in serum and for COPD group only blood gas analysis. Recruitment for the study was conducted from November to April. Statistical
analysis was performed using the following statistical methods: t-Student test, Mann-Whitney U test, Spearman correlation
test and Chi-kwadrat test.
Results: There was no significant differences between COPD and control group for the levels of 25(OH)D in serum. Median and
lower; upper quartile were respectively following: 24,75 nmol/l (16,9; 36,4) vs. 24,06 nmol/l (16,3; 37,2), p=0,69. Vitamin D
deficiency was present in 60 COPD patients (98,3% of all patients) and in 36 control group subject (97,3% of all healthy volunteers).
The difference was not statistically significant. The levels of vitamin D in serum did not significantly correlated with any
of studied parameters (spirometry, blood gas, age, the level of activity, BMI, tobacco smoke exposure and others). However, the
level of activity in COPD group correlated positively with spirometry values and negatively with age and number of exacerbations.
Conclusion: The results of the study showed that in autumn-winter time in Poland there are very frequent deficiency of vitamin
D in serum not only in COPD patients in respiratory failure stage but also in elderly healthy persons. However, in contrary to
expectations the deficiency of vitamin D in COPD patients with respiratory failure were similar to that seen in healthy persons.
Abstract
Introduction: The aim of the study was to measure the concentrations of vitamin D in serum of COPD patients with chronic respiratory
failure in comparison to healthy control group. The correlation between the levels of vitamin D in serum and the selected
clinical, spirometric and blood gas parameters was the additional aim of the study.
Material and methods: The study included 61 patients with diagnosed COPD in stadium of chronic respiratory failure (45 men
and 16 women) and 37 healthy controls (19 men and 18 women). The following procedure were performed in all studied subjects:
detailed history (especially: daily activity, diet, tobacco and alcohol use), post-bronchodilator spirometry, assessment of 25(OH)D
in serum and for COPD group only blood gas analysis. Recruitment for the study was conducted from November to April. Statistical
analysis was performed using the following statistical methods: t-Student test, Mann-Whitney U test, Spearman correlation
test and Chi-kwadrat test.
Results: There was no significant differences between COPD and control group for the levels of 25(OH)D in serum. Median and
lower; upper quartile were respectively following: 24,75 nmol/l (16,9; 36,4) vs. 24,06 nmol/l (16,3; 37,2), p=0,69. Vitamin D
deficiency was present in 60 COPD patients (98,3% of all patients) and in 36 control group subject (97,3% of all healthy volunteers).
The difference was not statistically significant. The levels of vitamin D in serum did not significantly correlated with any
of studied parameters (spirometry, blood gas, age, the level of activity, BMI, tobacco smoke exposure and others). However, the
level of activity in COPD group correlated positively with spirometry values and negatively with age and number of exacerbations.
Conclusion: The results of the study showed that in autumn-winter time in Poland there are very frequent deficiency of vitamin
D in serum not only in COPD patients in respiratory failure stage but also in elderly healthy persons. However, in contrary to
expectations the deficiency of vitamin D in COPD patients with respiratory failure were similar to that seen in healthy persons.
Keywords
COPD, vitamin D, chronic respiratory failure, long-term oxygen therapy
Supp./Additional Files (1)
About this articleTitle
Vitamin D status of severe COPD patients with chronic respiratory failure
Journal
Advances in Respiratory Medicine
Issue
Article type
Research paper
Pages
78-85
Published online
2018-04-30
DOI
10.5603/ARM.2018.0010
Pubmed
Bibliographic record
Adv Respir Med 2018;86(2):78-85.
Keywords
COPD
vitamin D
chronic respiratory failure
long-term oxygen therapy
Authors
Grzegorz Gawron
Marzena Trzaska-Sobczak
Ewa Sozańska
Piotr Śnieżek
Adam Barczyk
References (22)- Romme EA, Smeenk FW, Wouters EF. Osteoporosis in COPD. COPD and Comorbidity. European Respiratory Society Monograph. 2013; 59(9-10): 93–104.
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266–281.
- Bringhurst FR, Demay MB, Krane SM, et al. Metabolizm kości i składników mineralnych w stanie zdrowia i w chorobach [W:] Fauci AS, Braunwald E, Kasper DL. Interna Harrisona wydanie XVII, Lublin. ; 2009: 2624–2627.
- Chowdhury R, Kunutsor S, Vitezova A, et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014; 348: g1903.
- Skalska A, Fedak D, Gąsowski J. Stężenie 25-hydroksywitaminy D a stan odżywienia mierzony wskaźnikiem masy ciała u osób starszych. Gerontol Pol. 2009; 17: 16–22.
- Kmieć P, Żmijewski M, Waszak P. Niedobór witaminy D w przeważająco miejskiej populacji dorosłych z Województwa Pomorskiego w miesiącach zimowych. Endokrynologia Polska. 2014; 65(2): 105–113.
- Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska W, et al. Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland. Pol Arch Med Wewn. 2009; 119(11): 699–703.
- Płudowski P, Konstantynowicz J, Jaworski M, et al. Ocena stanu zaopatrzenia w witaminę D w populacji osób dorosłych w Polsce. Standardy Medyczne/Pediatria. 2014; 11: 609–617.
- Goldstein MF, Fallon JJ, Harning R. Chronic glucocorticoid therapy-induced osteoporosis in patients with obstructive lung disease. Chest. 1999; 116(6): 1733–1749.
- Bachta A, Kulig M, Tłustochowicz W. Osteoporoza posterydowa. Postępy Nauk Medycznych. 2012; XXV(3): 2012.
- Śliwiński P, Górecka D, Jassem E, et al. Zalecenia Polskiego Towarzystwa Chorób Płuc dotyczące rozpoznawania i leczenia przewlekłej obturacyjnej choroby płuc. Pneumonologia i Alergologia Polska. 2014; 82(3): 227–263.
- Janssens W, Lehouck An, Carremans C, et al. Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. Am J Respir Crit Care Med. 2009; 179(8): 630–636.
- Maltais F, Decramer M, Casaburi R, et al. ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014; 189(9): e15–e62.
- Janssens W, Bouillon R, Claes B, et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax. 2010; 65(3): 215–220.
- Hanson C, Rutten EPA, Wouters EFM, et al. Diet and vitamin D as risk factors for lung impairment and COPD. Transl Res. 2013; 162(4): 219–236.
- Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey. Chest. 2005; 128(6): 3792–3798.
- Khan S, Mai XM, Chen Y. Plasma 25-hydroxyvitamin D associated with pulmonary function in Canadian adults with excess adiposity. Am J Clin Nutr. 2013; 98(1): 174–179.
- Larose TL, Brumpton BM, Langhammer A, et al. Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study. Eur Respir J. 2015; 46(2): 355–363.
- Jackson AS, Shrikrishna D, Kelly JL, et al. Vitamin D and skeletal muscle strength and endurance in COPD. Eur Respir J. 2013; 41(2): 309–316.
- Pitkin AD, Roberts CM, Wedzicha JA. Arterialised earlobe blood gas analysis: an underused technique. Thorax. 1994; 49(4): 364–366.
- Dar K, Williams T, Aitken R, et al. Arterial versus capillary sampling for analysing blood gas pressures. BMJ. 1995; 310(6971): 24–25.
- Sauty A, Uldry C, Debétaz LF, et al. Differences in PO2 and PCO2 between arterial and arterialized earlobe samples. Eur Respir J. 1996; 9(2): 186–189.