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Primary pulmonary MALT lymphoma presenting as non-resolving pneumonia
open access
Abstract
Primary lung lymphoma (PLL) is a rare unilateral or bilateral lung disorder that is challenging to diagnose solely based on clinical and radiological presentation. PLL may be misdiagnosed as pneumonia or a lung tumor due to non-specific findings. PLL is most frequently a mucosa-associated lymphoid tissue (MALT) lymphoma, a type of extranodal low-grade B-cell lymphoma most commonly discovered in the gastrointestinal tract. PLL should be considered in the differential diagnosis of non-resolving pneumonias. Herein we present a case of an 84-year-old patient discovered to have a primary pulmonary MALT lymphoma presenting as a non-resolving pneumonia causing a clinical challenge.
Abstract
Primary lung lymphoma (PLL) is a rare unilateral or bilateral lung disorder that is challenging to diagnose solely based on clinical and radiological presentation. PLL may be misdiagnosed as pneumonia or a lung tumor due to non-specific findings. PLL is most frequently a mucosa-associated lymphoid tissue (MALT) lymphoma, a type of extranodal low-grade B-cell lymphoma most commonly discovered in the gastrointestinal tract. PLL should be considered in the differential diagnosis of non-resolving pneumonias. Herein we present a case of an 84-year-old patient discovered to have a primary pulmonary MALT lymphoma presenting as a non-resolving pneumonia causing a clinical challenge.
Keywords
primary pulmonary lymphoma, MALT lymphoma, non resolving pneumonia, lung cancer
About this articleTitle
Primary pulmonary MALT lymphoma presenting as non-resolving pneumonia
Journal
Advances in Respiratory Medicine
Issue
Article type
Case report
Pages
202-205
Published online
2017-07-31
DOI
10.5603/ARM.2017.0033
Pubmed
Bibliographic record
Adv Respir Med 2017;85(4):202-205.
Keywords
primary pulmonary lymphoma
MALT lymphoma
non resolving pneumonia
lung cancer
Authors
Asma Iftikhar
Albert Magh
Muhammed Azaz Cheema
Sarah Thappa
Sonu Sahni
Stephen Karbowitz
References (15)- Miller DL, Allen MS. Rare pulmonary neoplasms. Mayo Clin Proc. 1993; 68(5): 492–498.
- Cadranel J, Wislez M, Antoine M, et al. AIDS-related primary pulmonary lymphoma. Am J Respir Crit Care Med. 1998; 158(4): 1221–1229.
- Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983; 52(8): 1410–1416.
- Majid N, Kamal ElB, Oncology B, et al. Primary pulmonary lymphoma: About five cases and literature review. Lung India. 2014; 31(1): 53–55.
- Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 1994; 330(18): 1267–1271.
- Isaacson PG. Mucosa-associated lymphoid tissue lymphoma. Semin Hematol. . 1999; 36(2): 139–147.
- Borie R, Wislez M, Thabut G, et al. Clinical characteristics and prognostic factors of pulmonary MALT lymphoma. Eur Respir J. 2009; 34(6): 1408–1416.
- Kurtin PJ, Myers JL, Adlakha H, et al. Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol. 2001; 25(8): 997–1008.
- Cordier JF, Chailleux E, Lauque D, et al. Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest. 1993; 103(1): 201–208.
- Parissis H. Forty years literature review of primary lung lymphoma. J Cardiothorac Surg. 2011; 6: 23.
- Wannesson L, Cavalli F, Zucca E. Primary pulmonary lymphoma: current status. Clin Lymphoma Myeloma. 2005; 6(3): 220–227.
- Ferraro P, Trastek VF, Adlakha H, et al. Primary non-Hodgkin's lymphoma of the lung. Ann Thorac Surg. 2000; 69(4): 993–997.
- Poletti V, Romagna M, Gasponi A, et al. Bronchoalveolar lavage in the diagnosis of low-grade, MALT type, B-cell lymphoma in the lung. Monaldi Arch Chest Dis. 1995; 50(3): 191–194.
- Lee S, Kim MJ, Kim JS, et al. Consortium for Improving Survival of Lymphoma (CISL) study group. Phase II study of gemcitabine for treatment of patients with advanced stage marginal zone B-cell lymphoma: Consortium for Improving Survival of Lymphoma (CISL) trial. Invest New Drugs. 2010; 28(2): 171–177.
- Troch M, Streubel B, Petkov V, et al. Does MALT lymphoma of the lung require immediate treatment? An analysis of 11 untreated cases with long-term follow-up. Anticancer Res. 2007; 27(5B): 3633–3637.