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Ahead of Print
Review paper
Published online: 2020-12-17
Submitted: 2020-07-16
Accepted: 2020-08-16
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Evidence-based review of bronchoscopic lung volume reduction

Sumita Agrawal, Nitesh Gupta, Hari Kishan Gonuguntla, Hari Kishan Gonuguntla
DOI: 10.5603/ARM.a2020.0172

open access

Ahead of Print
REVIEWS
Published online: 2020-12-17
Submitted: 2020-07-16
Accepted: 2020-08-16

Abstract

Emphysema sequentially leads to the loss of gas exchanging surface and an abnormal shape of the diaphragm generating dyspnea refractory to standard medical therapy. Lung volume reduction surgery (LVRS) is a surgical treatment option for patients with severe emphysema whose symptoms are uncontrolled on standard therapy. Bronchoscopic LVR (bLVR) is a process by which lung volume reduction is achieved in a minimally invasive manner using bronchoscopy-guided insertion of valves, coils, sealants, or by thermal vapour ablation like techniques. These therapies have developed over the last few years and have variable results in patients. We have summarized the current evidence available on each of these methods in this review.

Abstract

Emphysema sequentially leads to the loss of gas exchanging surface and an abnormal shape of the diaphragm generating dyspnea refractory to standard medical therapy. Lung volume reduction surgery (LVRS) is a surgical treatment option for patients with severe emphysema whose symptoms are uncontrolled on standard therapy. Bronchoscopic LVR (bLVR) is a process by which lung volume reduction is achieved in a minimally invasive manner using bronchoscopy-guided insertion of valves, coils, sealants, or by thermal vapour ablation like techniques. These therapies have developed over the last few years and have variable results in patients. We have summarized the current evidence available on each of these methods in this review.

Get Citation

Keywords

bronchoscopy; pulmonary emphysema; treatment outcome

About this article
Title

Evidence-based review of bronchoscopic lung volume reduction

Journal

Advances in Respiratory Medicine

Issue

Ahead of Print

Article type

Review paper

Published online

2020-12-17

DOI

10.5603/ARM.a2020.0172

Keywords

bronchoscopy
pulmonary emphysema
treatment outcome

Authors

Sumita Agrawal
Nitesh Gupta
Hari Kishan Gonuguntla
Hari Kishan Gonuguntla

References (16)
  1. Browning RF, Parrish S, Sarkar S, et al. Bronchoscopic interventions for severe COPD. J Thorac Dis. 2014; 6(Suppl 4): S407–S415.
  2. Gülşen A. Bronchoscopic lung volume reduction: a 2018 review and update. Turk Thorac J. 2018; 19(3): 141–149.
  3. Sciurba FC, Ernst A, Herth FJF, et al. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 2010; 363(13): 1233–44.
  4. Valipour A, Herth FJF, Burghuber OC, et al. Target lobe volume reduction and COPD outcome measures after endobronchial valve therapy. Eur Respir J. 2014; 43(2): 387–396.
  5. Klooster K, ten Hacken NHT, Hartman JE, et al. Endobronchial valves for emphysema without interlobar collateral ventilation. N Engl J Med. 2015; 373(24): 2325–2335.
  6. Herth FJF, Noppen M, Valipour A, et al. Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort. Eur Respir J. 2012; 39(6): 1334–1342.
  7. Valipour A, Slebos DJ, Herth F, et al. Endobronchial valve therapy in patients with homogeneous emphysema. Results from the IMPACT study. Am J Respir Crit Care Med. 2016; 194(9): 1073–1082.
  8. Kemp SV, Slebos DJ, Kirk A, et al. A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (TRANSFORM). Am J Respir Crit Care Med. 2017; 196(12): 1535–1543.
  9. Li S, Wang G, Wang C, et al. The REACH trial: a randomized controlled trial assessing the safety and effectiveness of the spiration® valve system in the treatment of severe emphysema. Respiration. 2019; 97(5): 416–427.
  10. Jem VA, Hnin K, Grosser D, et al. Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease. Cochrane Library. 23 February 2017 . Available at: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012158.pub2/full. [Last accessed: 26.10.2020].
  11. Shah P, Zoumot Z, Singh S, et al. Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial. The Lancet Respiratory Medicine. 2013; 1(3): 233–240.
  12. Deslée G, Mal H, Dutau H, et al. Lung volume reduction coil treatment vs usual care in patients with severe emphysema: the REVOLENS randomized clinical trial. JAMA. 2016; 315(2): 175–184.
  13. Sciurba FC, Criner GJ, Strange C, et al. Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: the RENEW randomized clinical trial. JAMA. 2016; 315(20): 2178–2189.
  14. Herth F, Shah P, Valipour A, et al. STEP-UP randomized controlled trial of vapor ablation in patients with severe emphysema: 12 month results. 1.4 Interventional Pulmonology. 2016.
  15. Come CE, Kramer MR, Dransfield MT, et al. A randomised trial of lung sealant versus medical therapy for advanced emphysema. Eur Respir J. 2015; 46(3): 651–662.
  16. Shah PL, Slebos DJ, Cardoso P, et al. Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial. The Lancet. 2011; 378(9795): 997–1005.

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