open access

Vol 88, No 4 (2020)
LETTERS
Published online: 2020-06-16
Submitted: 2020-05-04
Accepted: 2020-05-23
Get Citation

Vitamin D supplementation to prevent COVID-19 in patients with COPD: a research perspective

Malek Chaabouni, Walid Feki, Khansa Chaabouni, Samy Kammoun
DOI: 10.5603/ARM.a2020.0101
·
Pubmed: 32869273
·
Adv Respir Med 2020;88(4):364-365.

open access

Vol 88, No 4 (2020)
LETTERS
Published online: 2020-06-16
Submitted: 2020-05-04
Accepted: 2020-05-23

Abstract

There is increased evidence that the massive release of pro-inflammatory cytokines leading to the cytokine storm syndrome shapes the evolution of COVID-19 and is responsible of the severity of COVID-19 in some patients. A recent review argued that vitamin D deficiency could have increased the COVID-19 outbreak and suggested vitamin D supplementation as a preventive action. In fact, many factors seem to be correlated both to low vitamin D levels and the importance of COVID-19 spreading and severity. It is also important to highlight that the lockdown, implemented in many countries, prevents people to go out and then increases the risk of vitamin D deficiency. COPD patients are particularly at risk to have low levels of vitamin D due to multiple risk factors. COPD may generate a systemic inflammatory process responsible of secondary extra-pulmonary impairments. Vitamin D deficiency could sustain and aggravate the systemic inflammation associated to COPD. Reports have also shown that vitamin D deficiency was associated to exacerbations and hospital admissions, as well as lung function. Recent research showed that vitamin D supplementation significantly reduced COPD exacerbations. Although vitamin D deficiency was not proved to be neither a risk factor of COVID-19, nor a determinant of its severity, vitamin D supplementation represents a preventive perspective that needs to be further studied.

Abstract

There is increased evidence that the massive release of pro-inflammatory cytokines leading to the cytokine storm syndrome shapes the evolution of COVID-19 and is responsible of the severity of COVID-19 in some patients. A recent review argued that vitamin D deficiency could have increased the COVID-19 outbreak and suggested vitamin D supplementation as a preventive action. In fact, many factors seem to be correlated both to low vitamin D levels and the importance of COVID-19 spreading and severity. It is also important to highlight that the lockdown, implemented in many countries, prevents people to go out and then increases the risk of vitamin D deficiency. COPD patients are particularly at risk to have low levels of vitamin D due to multiple risk factors. COPD may generate a systemic inflammatory process responsible of secondary extra-pulmonary impairments. Vitamin D deficiency could sustain and aggravate the systemic inflammation associated to COPD. Reports have also shown that vitamin D deficiency was associated to exacerbations and hospital admissions, as well as lung function. Recent research showed that vitamin D supplementation significantly reduced COPD exacerbations. Although vitamin D deficiency was not proved to be neither a risk factor of COVID-19, nor a determinant of its severity, vitamin D supplementation represents a preventive perspective that needs to be further studied.

Get Citation

Keywords

coronavirus; COVID-19; COPD; prevention; vitamin D

About this article
Title

Vitamin D supplementation to prevent COVID-19 in patients with COPD: a research perspective

Journal

Advances in Respiratory Medicine

Issue

Vol 88, No 4 (2020)

Pages

364-365

Published online

2020-06-16

DOI

10.5603/ARM.a2020.0101

Pubmed

32869273

Bibliographic record

Adv Respir Med 2020;88(4):364-365.

Keywords

coronavirus
COVID-19
COPD
prevention
vitamin D

Authors

Malek Chaabouni
Walid Feki
Khansa Chaabouni
Samy Kammoun

References (10)
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