open access

Vol 87, No 6 (2019)
ORIGINAL PAPERS
Published online: 2020-01-14
Submitted: 2019-06-11
Accepted: 2019-11-05
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Relationship between CHA2DS2-VASc and CHADS2 scores with pulmonary hypertension in patients with acute pulmonary embolism

Samet Yilmaz, Yalin Tolga Yaylali, Mevlüt Serdar Kuyumcu, Sefa Ünal, Hande Senol, Omac Tufekcioglu
DOI: 10.5603/ARM.2019.0057
·
Pubmed: 31970721
·
Adv Respir Med 2019;87(6):203-208.

open access

Vol 87, No 6 (2019)
ORIGINAL PAPERS
Published online: 2020-01-14
Submitted: 2019-06-11
Accepted: 2019-11-05

Abstract

Introduction: Pulmonary hypertension (PH) is the most important prognostic factor after acute pulmonary embolism (PE). Therefore, determination of patients who will develop PH after acute PE is crucial.  The aim of the present study was to evaluate the predictive value of the CHADS2 and CHA2DS2-VASc scores for PH in patients with acute PE.
Material and methods: Seventy-nine adults who presented with acute PE, had an admission systolic pulmonary artery pressure (sPAP) measured on echocardiogram and no previous history of PE, were retrospectively identified from the computerized database. 31 patients who had sPAP ≤ 40 mm Hg were categorized as a  “normal pulmonary pressure” group, whereas 48 patients who had sPAP > 40 mm Hg were categorized as a “PH” group.
Results: SPAP was > 40 mm Hg in 48 patients (60.8%), with a mean sPAP of 60.9 ± 16.1 mm Hg (median = 60, min–max = 41–100 mm Hg). In multivariate logistic regression models adjusted for CHADS2 and CHA2DS2-VASc score components, only age was found to be related with the development of PH. SPAP was weakly positively correlated with CHADS2 (p = 0.047; r = 0.224) and CHA2DS2-VASc (p = 0.023; r = 0.256) scores. SPAP values were increasing with the severity of the scores.
Conclusions: Both CHADS2 and CHA2DS2-VASc scores could be useful in the determination of which patients should be closely followed up in order to prevent the development of PH after acute PE.

Abstract

Introduction: Pulmonary hypertension (PH) is the most important prognostic factor after acute pulmonary embolism (PE). Therefore, determination of patients who will develop PH after acute PE is crucial.  The aim of the present study was to evaluate the predictive value of the CHADS2 and CHA2DS2-VASc scores for PH in patients with acute PE.
Material and methods: Seventy-nine adults who presented with acute PE, had an admission systolic pulmonary artery pressure (sPAP) measured on echocardiogram and no previous history of PE, were retrospectively identified from the computerized database. 31 patients who had sPAP ≤ 40 mm Hg were categorized as a  “normal pulmonary pressure” group, whereas 48 patients who had sPAP > 40 mm Hg were categorized as a “PH” group.
Results: SPAP was > 40 mm Hg in 48 patients (60.8%), with a mean sPAP of 60.9 ± 16.1 mm Hg (median = 60, min–max = 41–100 mm Hg). In multivariate logistic regression models adjusted for CHADS2 and CHA2DS2-VASc score components, only age was found to be related with the development of PH. SPAP was weakly positively correlated with CHADS2 (p = 0.047; r = 0.224) and CHA2DS2-VASc (p = 0.023; r = 0.256) scores. SPAP values were increasing with the severity of the scores.
Conclusions: Both CHADS2 and CHA2DS2-VASc scores could be useful in the determination of which patients should be closely followed up in order to prevent the development of PH after acute PE.

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Keywords

CHA2DS2-VASc score, CHADS2 score, pulmonary hypertension, acute pulmonary embolism

About this article
Title

Relationship between CHA2DS2-VASc and CHADS2 scores with pulmonary hypertension in patients with acute pulmonary embolism

Journal

Advances in Respiratory Medicine

Issue

Vol 87, No 6 (2019)

Pages

203-208

Published online

2020-01-14

DOI

10.5603/ARM.2019.0057

Pubmed

31970721

Bibliographic record

Adv Respir Med 2019;87(6):203-208.

Keywords

CHA2DS2-VASc score
CHADS2 score
pulmonary hypertension
acute pulmonary embolism

Authors

Samet Yilmaz
Yalin Tolga Yaylali
Mevlüt Serdar Kuyumcu
Sefa Ünal
Hande Senol
Omac Tufekcioglu

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