open access

Vol 87, No 2 (2019)
ORIGINAL PAPERS
Published online: 2019-04-05
Submitted: 2018-12-28
Accepted: 2019-03-20
Get Citation

Impact on survival of nuclear atypia in epithelioid malignant mesothelioma

Mona Mlika, Manel Limam, Aida Benzarti, Faouzi Mezni
DOI: 10.5603/ARM.2019.0015
·
Pubmed: 31038719
·
Adv Respir Med 2019;87(2):90-95.

open access

Vol 87, No 2 (2019)
ORIGINAL PAPERS
Published online: 2019-04-05
Submitted: 2018-12-28
Accepted: 2019-03-20

Abstract

Introduction: Malignant pleural mesothelioma is a rare tumour with a bad prognosis. The only consensual prognostic factors
are represented by the stage and the histologic type. Concerning the histologic type, epithelioid mesothelioma is known to have
better prognosis in comparison with the sarcomatoid and biphasic types. Epithelioid mesotheliomas have been reported to be
a heterogeneous prognostic group. Our aim was to assess the impact on the survival of different characteristics of epithelioid
mesothelioma, including nuclear atypia, mitotic count, MIB-1 index, inflammatory host response, stromal desmoplasia, necrosis,
vascular emboli and invasion depth.

Material and methods: We performed a study of survival of 30 malignant pleural mesotheliomas according to the different
parameters studied.

Results: The study included 26 women and 4 men. The mean age of the patients was 61 years. The microscopic exam concluded
to an epithelioid mesothelioma in 17 cases, sarcomatoid mesothelioma in 4 cases and biphasic mesothelioma in 9 cases. The 17
cases of epithelioid mesothelioma developed severe nuclear atypia in 6 cases and mild nuclear atypia in 11 cases. The mitotic
count and the MIB-1 score were respectively inferior to 5 mitoses/50 HPF and inferior to 10% in 11 cases and were superior to
5 mitoses/50 HPF and superior to 10% in 6 cases. No vascular emboli were recorded. Tumour necrosis was reported in 1 case.
The inflammatory host response was severe in 4 cases and mild in 13 cases. The tumoral stroma was desmoplastic in 4 cases.
The invasion depth was superior to 0.5mm in 16 cases. The median overall survival amounted to 180 days. Nuclear atypia was
the only feature that had impact on survival in the group of epithelioid mesothelioma.

Conclusion: Our results highlight the correlation of nuclear atypia with survival.

Abstract

Introduction: Malignant pleural mesothelioma is a rare tumour with a bad prognosis. The only consensual prognostic factors
are represented by the stage and the histologic type. Concerning the histologic type, epithelioid mesothelioma is known to have
better prognosis in comparison with the sarcomatoid and biphasic types. Epithelioid mesotheliomas have been reported to be
a heterogeneous prognostic group. Our aim was to assess the impact on the survival of different characteristics of epithelioid
mesothelioma, including nuclear atypia, mitotic count, MIB-1 index, inflammatory host response, stromal desmoplasia, necrosis,
vascular emboli and invasion depth.

Material and methods: We performed a study of survival of 30 malignant pleural mesotheliomas according to the different
parameters studied.

Results: The study included 26 women and 4 men. The mean age of the patients was 61 years. The microscopic exam concluded
to an epithelioid mesothelioma in 17 cases, sarcomatoid mesothelioma in 4 cases and biphasic mesothelioma in 9 cases. The 17
cases of epithelioid mesothelioma developed severe nuclear atypia in 6 cases and mild nuclear atypia in 11 cases. The mitotic
count and the MIB-1 score were respectively inferior to 5 mitoses/50 HPF and inferior to 10% in 11 cases and were superior to
5 mitoses/50 HPF and superior to 10% in 6 cases. No vascular emboli were recorded. Tumour necrosis was reported in 1 case.
The inflammatory host response was severe in 4 cases and mild in 13 cases. The tumoral stroma was desmoplastic in 4 cases.
The invasion depth was superior to 0.5mm in 16 cases. The median overall survival amounted to 180 days. Nuclear atypia was
the only feature that had impact on survival in the group of epithelioid mesothelioma.

Conclusion: Our results highlight the correlation of nuclear atypia with survival.

Get Citation

Keywords

malignant mesothelioma, prognosis, epithelioid mesothelioma

About this article
Title

Impact on survival of nuclear atypia in epithelioid malignant mesothelioma

Journal

Advances in Respiratory Medicine

Issue

Vol 87, No 2 (2019)

Pages

90-95

Published online

2019-04-05

DOI

10.5603/ARM.2019.0015

Pubmed

31038719

Bibliographic record

Adv Respir Med 2019;87(2):90-95.

Keywords

malignant mesothelioma
prognosis
epithelioid mesothelioma

Authors

Mona Mlika
Manel Limam
Aida Benzarti
Faouzi Mezni

References (9)
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