open access

Vol 87, No 1 (2019)
ORIGINAL PAPERS
Published online: 2019-03-04
Submitted: 2018-10-28
Accepted: 2019-01-03
Get Citation

Interrelationship of endothelial function parameters in children with bronchial asthma in exacerbation and remission

Dmytro Butov, Nataliia Makieieva, Yuliia Vasylchenko, Maryna Biriukova, Kateryna Serhiienko, Oleksandr Morozov
DOI: 10.5603/ARM.a2019.0002
·
Pubmed: 30830954
·
Adv Respir Med 2019;87(1):7-13.

open access

Vol 87, No 1 (2019)
ORIGINAL PAPERS
Published online: 2019-03-04
Submitted: 2018-10-28
Accepted: 2019-01-03

Abstract

Introduction: In children with asthma, endothelial dysfunction signs are observed, and their extent depends on the severity of the disease.
These changes are also present in remission. High level of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) expression causes active
adhesion of inflammatory cells and can indicate direct endothelium participation in development and supporting of chronic inflammation.
Bronchial asthma (BA) is characterised by airways chronic inflammation. A special role in this inflammatory process formation
is played by development of endothelial dysfunction.
The aim of the study was to evaluate endothelial state in children with clinically stable and exacerbated asthma.

Material and methods: 91 children with persistent asthma were examined. Among them there were 40 patients with mild persistent
(group I), 34 subjects with moderate persistent (group II) and 17 individuals with severe persistent (group III) asthma. 20 healthy children
were selected as controls. The serum levels of sVCAM-1 were determined by enzyme-linked immunosorbent assay (ELISA). The ultrasound
assessment of endothelium-dependent flow-mediated dilation of the brachial artery (FMD%) has been made. Ultrasonography has been used
for investigation of the intima-media thickness (I-M) complex. Data analysis was performed with the Statsoft Statistica Version 8 (Tulsa, OK).

Results: The serum levels of sVCAM-1 were significantly increased in the patients with asthma exacerbation (p < 0.001) and
remission (p < 0.001), compared with the controls. The index of FMD% was significantly diminished in the patients of I, II, III
group with exacerbation (p < 0.001) and stayed lower in the subjects with asthma in remission (p < 0.001), compared with the
controls. The thickness of I-M complex was significantly increased in the patients of I, II, III group, compared with the controls
(p < 0.001). The endothelium parameter levels: sVCAM-1 (H = 56.11, p = 0.0001), FMD% (H = 43.20, p = 0.0000), the thickness
of I-M complex (H = 49.37, p = 0.0000) depend on the severity of the disease. Correlations between the endothelium and
pulmonary function parameters were proved (p < 0.05).

Conclusions: Endothelial dysfunction in children with asthma was determined. Dependence of severity of the disease on functional
state of the vascular endothelium was proved.

Abstract

Introduction: In children with asthma, endothelial dysfunction signs are observed, and their extent depends on the severity of the disease.
These changes are also present in remission. High level of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) expression causes active
adhesion of inflammatory cells and can indicate direct endothelium participation in development and supporting of chronic inflammation.
Bronchial asthma (BA) is characterised by airways chronic inflammation. A special role in this inflammatory process formation
is played by development of endothelial dysfunction.
The aim of the study was to evaluate endothelial state in children with clinically stable and exacerbated asthma.

Material and methods: 91 children with persistent asthma were examined. Among them there were 40 patients with mild persistent
(group I), 34 subjects with moderate persistent (group II) and 17 individuals with severe persistent (group III) asthma. 20 healthy children
were selected as controls. The serum levels of sVCAM-1 were determined by enzyme-linked immunosorbent assay (ELISA). The ultrasound
assessment of endothelium-dependent flow-mediated dilation of the brachial artery (FMD%) has been made. Ultrasonography has been used
for investigation of the intima-media thickness (I-M) complex. Data analysis was performed with the Statsoft Statistica Version 8 (Tulsa, OK).

Results: The serum levels of sVCAM-1 were significantly increased in the patients with asthma exacerbation (p < 0.001) and
remission (p < 0.001), compared with the controls. The index of FMD% was significantly diminished in the patients of I, II, III
group with exacerbation (p < 0.001) and stayed lower in the subjects with asthma in remission (p < 0.001), compared with the
controls. The thickness of I-M complex was significantly increased in the patients of I, II, III group, compared with the controls
(p < 0.001). The endothelium parameter levels: sVCAM-1 (H = 56.11, p = 0.0001), FMD% (H = 43.20, p = 0.0000), the thickness
of I-M complex (H = 49.37, p = 0.0000) depend on the severity of the disease. Correlations between the endothelium and
pulmonary function parameters were proved (p < 0.05).

Conclusions: Endothelial dysfunction in children with asthma was determined. Dependence of severity of the disease on functional
state of the vascular endothelium was proved.

Get Citation

Keywords

bronchial asthma, endothelium, inflammation, children

About this article
Title

Interrelationship of endothelial function parameters in children with bronchial asthma in exacerbation and remission

Journal

Advances in Respiratory Medicine

Issue

Vol 87, No 1 (2019)

Pages

7-13

Published online

2019-03-04

DOI

10.5603/ARM.a2019.0002

Pubmed

30830954

Bibliographic record

Adv Respir Med 2019;87(1):7-13.

Keywords

bronchial asthma
endothelium
inflammation
children

Authors

Dmytro Butov
Nataliia Makieieva
Yuliia Vasylchenko
Maryna Biriukova
Kateryna Serhiienko
Oleksandr Morozov

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