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Vol 86, No 1 (2018)
REVIEWS
Published online: 2018-01-21
Submitted: 2017-11-08
Accepted: 2018-01-05
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Inflammatory myofibroblastic tumor of the lung

Akshay Khatri, Abhinav Agrawal, Rutuja R Sikachi, Dhruv Mehta, Sonu Sahni, Nikhil Meena
DOI: 10.5603/ARM.2018.0007
·
Pubmed: 29490419
·
Adv Respir Med 2018;86(1):27-35.

open access

Vol 86, No 1 (2018)
REVIEWS
Published online: 2018-01-21
Submitted: 2017-11-08
Accepted: 2018-01-05

Abstract

Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo
-tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma
cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation,
recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune
diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms
or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung.
We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.

Abstract

Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo
-tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma
cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation,
recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune
diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms
or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung.
We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.

Get Citation

Keywords

inflammatory myofibroblastic tumor of the lung (IMT), inflammatory pseudo-tumor (IPT), pulmonary neoplasm, ALK, bronchoscopy

About this article
Title

Inflammatory myofibroblastic tumor of the lung

Journal

Advances in Respiratory Medicine

Issue

Vol 86, No 1 (2018)

Pages

27-35

Published online

2018-01-21

DOI

10.5603/ARM.2018.0007

Pubmed

29490419

Bibliographic record

Adv Respir Med 2018;86(1):27-35.

Keywords

inflammatory myofibroblastic tumor of the lung (IMT)
inflammatory pseudo-tumor (IPT)
pulmonary neoplasm
ALK
bronchoscopy

Authors

Akshay Khatri
Abhinav Agrawal
Rutuja R Sikachi
Dhruv Mehta
Sonu Sahni
Nikhil Meena

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