open access

Vol 85, No 6 (2017)
ORIGINAL PAPERS
Published online: 2017-12-06
Submitted: 2017-09-26
Accepted: 2017-11-17
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Cryobiopsy versus forceps biopsy in endobronchial lesions, diagnostic yield and safety

Ahmed Ehab, Mohammad Khairy El-Badrawy, Amr Abdelhamed Moawad, Mohammad El-Dosouky Abo-Shehata
DOI: 10.5603/ARM.2017.0052
·
Pubmed: 29288478
·
Adv Respir Med 2017;85(6):301-306.

open access

Vol 85, No 6 (2017)
ORIGINAL PAPERS
Published online: 2017-12-06
Submitted: 2017-09-26
Accepted: 2017-11-17

Abstract

Introduction: This study aimed to evaluate the safety and diagnostic yield of CB in comparison to forceps biopsy in endobronchial lesions. Material and methods: Patients with suspected endobronchial lesions were enrolled. Two forceps biopsies and one cryobiopsy were done in the same patient with randomized sequence. The largest diameter of the samples was measured in mm by electronic caliper. Diagnostic yield of each technique and postbronchoscopy bleeding were evaluated. Results: Samples obtained by CB was significantly larger than that of the forceps biopsy (5.9 ± 2.3 vs 2.5 ± 0.8), (p = 0.001). Diagnostic yield of CB was significantly higher than forceps biopsy 74.5% versus 51.1% (p = 0.001). Mild and moderate bleeding grades were reported in both techniques with no significant difference (p = 0.063) (p = 0.5) respectively. Severe bleeding was not recorded in both techniques. Conclusions: CB represents a safe and effective tool to obtain a larger tissue samples of a good quality with higher diagnostic yield in comparison to standard forceps samples. On the other hand, bleeding occurred more frequently after CB than forceps biopsy. However, without severe adverse effects.

Abstract

Introduction: This study aimed to evaluate the safety and diagnostic yield of CB in comparison to forceps biopsy in endobronchial lesions. Material and methods: Patients with suspected endobronchial lesions were enrolled. Two forceps biopsies and one cryobiopsy were done in the same patient with randomized sequence. The largest diameter of the samples was measured in mm by electronic caliper. Diagnostic yield of each technique and postbronchoscopy bleeding were evaluated. Results: Samples obtained by CB was significantly larger than that of the forceps biopsy (5.9 ± 2.3 vs 2.5 ± 0.8), (p = 0.001). Diagnostic yield of CB was significantly higher than forceps biopsy 74.5% versus 51.1% (p = 0.001). Mild and moderate bleeding grades were reported in both techniques with no significant difference (p = 0.063) (p = 0.5) respectively. Severe bleeding was not recorded in both techniques. Conclusions: CB represents a safe and effective tool to obtain a larger tissue samples of a good quality with higher diagnostic yield in comparison to standard forceps samples. On the other hand, bleeding occurred more frequently after CB than forceps biopsy. However, without severe adverse effects.
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Keywords

cryobiopsy, forceps biopsy, lung cancer, bronchoscopy, endobronchial lesion

About this article
Title

Cryobiopsy versus forceps biopsy in endobronchial lesions, diagnostic yield and safety

Journal

Advances in Respiratory Medicine

Issue

Vol 85, No 6 (2017)

Pages

301-306

Published online

2017-12-06

DOI

10.5603/ARM.2017.0052

Pubmed

29288478

Bibliographic record

Adv Respir Med 2017;85(6):301-306.

Keywords

cryobiopsy
forceps biopsy
lung cancer
bronchoscopy
endobronchial lesion

Authors

Ahmed Ehab
Mohammad Khairy El-Badrawy
Amr Abdelhamed Moawad
Mohammad El-Dosouky Abo-Shehata

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