open access

Vol 85, No 2 (2017)
REVIEWS
Published online: 2017-04-24
Submitted: 2017-01-15
Accepted: 2017-03-20
Get Citation

Selected bone morphogenetic proteins — the possibility of their use in the diagnostics and therapy of severe asthma

Marcelina Koćwin, Mateusz Jonakowski, Marcelina Przemęcka, Michał Panek, Piotr Kuna
DOI: 10.5603/ARM.2017.0017
·
Adv Respir Med 2017;85(2):109-115.

open access

Vol 85, No 2 (2017)
REVIEWS
Published online: 2017-04-24
Submitted: 2017-01-15
Accepted: 2017-03-20

Abstract

Asthma is a chronic heterogeneous illness of the lower airway with an inflammatory basis, developing from hyperresponsiveness and bronchial obstruction. One of the more unfavourable processes occurring in the airway are the long-term changes of the respiratory tract known as remodelling, resulting in complete irreversible obstruction. Bone morphogenetic protein (BMP) is a member of the Transforming Growth Factor beta (TGF-b) superfamily, which regulates processes in embryonic and post-embryonic development. The role played by BMP is regulation of degradation and remodelling of the extracellular matrix, which is one of the elements involved in the reconstruction of the structure of the bronchi in severe asthma. This paper presents the antagonistic properties of BMP against TGF-b, anti-inflammatory and counteracting fibrosis in the respiratory tract. The current state of knowledge indicates that this group of cytokines are potential new markers of remodelling in severe asthma, and further studies on their therapeutic value are necessary.

Abstract

Asthma is a chronic heterogeneous illness of the lower airway with an inflammatory basis, developing from hyperresponsiveness and bronchial obstruction. One of the more unfavourable processes occurring in the airway are the long-term changes of the respiratory tract known as remodelling, resulting in complete irreversible obstruction. Bone morphogenetic protein (BMP) is a member of the Transforming Growth Factor beta (TGF-b) superfamily, which regulates processes in embryonic and post-embryonic development. The role played by BMP is regulation of degradation and remodelling of the extracellular matrix, which is one of the elements involved in the reconstruction of the structure of the bronchi in severe asthma. This paper presents the antagonistic properties of BMP against TGF-b, anti-inflammatory and counteracting fibrosis in the respiratory tract. The current state of knowledge indicates that this group of cytokines are potential new markers of remodelling in severe asthma, and further studies on their therapeutic value are necessary.

Get Citation

Keywords

bone morphogenetic proteins, BMP signalling pathway, inflammation, remodelling, asthma

Supplementary Files (2)
ABSTRACT polish
Download
18KB
Untitled
Download
39KB
About this article
Title

Selected bone morphogenetic proteins — the possibility of their use in the diagnostics and therapy of severe asthma

Journal

Advances in Respiratory Medicine

Issue

Vol 85, No 2 (2017)

Pages

109-115

Published online

2017-04-24

DOI

10.5603/ARM.2017.0017

Bibliographic record

Adv Respir Med 2017;85(2):109-115.

Keywords

bone morphogenetic proteins
BMP signalling pathway
inflammation
remodelling
asthma

Authors

Marcelina Koćwin
Mateusz Jonakowski
Marcelina Przemęcka
Michał Panek
Piotr Kuna

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl