open access

Vol 84, No 5 (2016)
REVIEWS
Submitted: 2016-09-27
Accepted: 2016-09-27

The role of the TGF-SMAD signalling pathway in the etiopathogenesis of severe asthma

Marcelina Koćwin, Mateusz Jonakowski, Marcelina Przemęcka, Jan Zioło, Michał Panek, Piotr Kuna
DOI: 10.5603/PiAP.2016.0037
·
Pneumonol Alergol Pol 2016;84(5):290-301.

open access

Vol 84, No 5 (2016)
REVIEWS
Submitted: 2016-09-27
Accepted: 2016-09-27

Abstract

Asthma is a chronic inflammatory heterogeneous disease of the lower respiratory tract characterised by the occurrence of bronchial hyper-responsiveness and paroxysmal, changeable bronchial obstruction. Transforming growth factor-beta (TGF-b) is one of the cytokines involved in mediating airway inflammation and remodelling. The level of TGF-b1 gene expression correlates with severity of symptoms. Alterations in the main SMAD signal transmission, overexpression of TGF-b genes and changes in the transcriptome cause excessive secretion of TGF-b and its increased expression in target cells, which clinically induces a moderate-severe or severe course of asthma as well as an earlier and faster disease progression. Knowledge of these processes allows clinicians to assess immune responses in patients, which affects adequate disease control and prevention of remodelling.

Keywords

transforming growth factor b TGF-b, signalling proteins SMAD, remodelling; severe asthma

About this article
Title

The role of the TGF-SMAD signalling pathway in the etiopathogenesis of severe asthma

Journal

Advances in Respiratory Medicine

Issue

Vol 84, No 5 (2016)

Pages

290-301

DOI

10.5603/PiAP.2016.0037

Bibliographic record

Pneumonol Alergol Pol 2016;84(5):290-301.

Keywords

transforming growth factor b TGF-b
signalling proteins SMAD
remodelling
severe asthma

Authors

Marcelina Koćwin
Mateusz Jonakowski
Marcelina Przemęcka
Jan Zioło
Michał Panek
Piotr Kuna

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