open access

Vol 84, No 2 (2016)
ORIGINAL PAPERS
Submitted: 2016-03-23
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Low DLCO in idiopathic pulmonary arterial hypertension — clinical correlates and prognostic significance

Monika Szturmowicz, Aneta Kacprzak, Monika Franczuk, Barbara Burakowska, Marcin Kurzyna, Anna Fijałkowska, Agnieszka Skoczylas, Stefan Wesołowski, Jan Kuś, Adam Torbicki
DOI: 10.5603/PiAP.2016.0006
·
Pneumonol Alergol Pol 2016;84(2):87-94.

open access

Vol 84, No 2 (2016)
ORIGINAL PAPERS
Submitted: 2016-03-23

Abstract

INTRODUCTION: Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance is uncertain. We aimed to assess clinical correlates and prognostic significance of low DLCO in IPAH patients.

MATERIAL AND METHODS: In the group of 65 IPAH patients the cut off value for low DLCO was set up based on histogram as < 55% of predicted value. Demographic data, exercise capacity, lung function tests, hemodynamic parameters and survival of the patients were compared depending on DLCO value.

RESULTS: Low DLCO was found in 18% of the patients, and it was associated with male sex, older age, worse functional status and exercise capacity, and higher prevalence of coronary artery disease. Low DLCO carried a 4-fold increase of death risk in 5-year perspective.

CONCLUSIONS: Low DLCO was a marker of worse functional capacity and increased risk of death in studied IPAH patients.

Abstract

INTRODUCTION: Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance is uncertain. We aimed to assess clinical correlates and prognostic significance of low DLCO in IPAH patients.

MATERIAL AND METHODS: In the group of 65 IPAH patients the cut off value for low DLCO was set up based on histogram as < 55% of predicted value. Demographic data, exercise capacity, lung function tests, hemodynamic parameters and survival of the patients were compared depending on DLCO value.

RESULTS: Low DLCO was found in 18% of the patients, and it was associated with male sex, older age, worse functional status and exercise capacity, and higher prevalence of coronary artery disease. Low DLCO carried a 4-fold increase of death risk in 5-year perspective.

CONCLUSIONS: Low DLCO was a marker of worse functional capacity and increased risk of death in studied IPAH patients.

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Keywords

diffusing capacity for carbon monoxide, pulmonary hypertension, prognostic factor

About this article
Title

Low DLCO in idiopathic pulmonary arterial hypertension — clinical correlates and prognostic significance

Journal

Advances in Respiratory Medicine

Issue

Vol 84, No 2 (2016)

Pages

87-94

DOI

10.5603/PiAP.2016.0006

Bibliographic record

Pneumonol Alergol Pol 2016;84(2):87-94.

Keywords

diffusing capacity for carbon monoxide
pulmonary hypertension
prognostic factor

Authors

Monika Szturmowicz
Aneta Kacprzak
Monika Franczuk
Barbara Burakowska
Marcin Kurzyna
Anna Fijałkowska
Agnieszka Skoczylas
Stefan Wesołowski
Jan Kuś
Adam Torbicki

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