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Arterial and venous thromboembolism in chronic obstructive pulmonary disease: from pathogenic mechanisms to prevention and treatment
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Abstract
Chronic obstructive pulmonary disease (COPD) affects approximately 10% of adults older than 40 years and is an important causes of disability and death in elderly subjects. A large proportion of COPD patients suffer from cardiovascular comorbidities. Thromboembolic events contribute considerably to morbidity and mortality in these subjects. This review summarizes the current evidence regarding the association of COPD with increased thromboembolic risk. We discuss multiple mechanisms potentially linking these conditions and available pharmacological interventions reducing the risk of thrombotic arterial and venous events with special attention paid to new oral anticoagulants.
Abstract
Chronic obstructive pulmonary disease (COPD) affects approximately 10% of adults older than 40 years and is an important causes of disability and death in elderly subjects. A large proportion of COPD patients suffer from cardiovascular comorbidities. Thromboembolic events contribute considerably to morbidity and mortality in these subjects. This review summarizes the current evidence regarding the association of COPD with increased thromboembolic risk. We discuss multiple mechanisms potentially linking these conditions and available pharmacological interventions reducing the risk of thrombotic arterial and venous events with special attention paid to new oral anticoagulants.
Keywords
anticoagulants, COPD, cardiovascular, coagulation, thrombosis
About this articleTitle
Arterial and venous thromboembolism in chronic obstructive pulmonary disease: from pathogenic mechanisms to prevention and treatment
Journal
Advances in Respiratory Medicine
Issue
Article type
Review paper
Pages
485-494
DOI
10.5603/PiAP.2015.0078
Pubmed
Bibliographic record
Pneumonol Alergol Pol 2015;83(6):485-494.
Keywords
anticoagulants
COPD
cardiovascular
coagulation
thrombosis
Authors
Filip Mejza
Bernd Lamprecht
Ewa Niżankowska-Mogilnicka
Anetta Undas