open access

Vol 83, No 6 (2015)
REVIEWS
Submitted: 2015-11-10
Accepted: 2015-11-10
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Selected molecular events in the pathogenesis of sarcoidosis — recent advances

Justyna Kiszałkiewicz, Wojciech J. Piotrowski, Ewa Brzeziańska-Lasota
DOI: 10.5603/PiAP.2015.0076
·
Pneumonol Alergol Pol 2015;83(6):462-475.

open access

Vol 83, No 6 (2015)
REVIEWS
Submitted: 2015-11-10
Accepted: 2015-11-10

Abstract

Sarcoidosis is an orphan inflammatory disorder that can virtually affect any organ or system in the body, although the lungs and lymph nodes are most frequently involved. Sarcoidosis is believed to derive from an interaction between environmental and genetic agents. Many studies emphasize a strong association between certain human leukocyte antigen (HLA) alleles and sarcoidosis susceptibility. Several new insights have allowed the further evaluation of other candidate genes with a potential function in the immunopathogenesis of sarcoidosis. This review summarizes recent advances in the identification of novel molecular markers that may play a role in different stages of disease, such as the acute phase of inflammation, granuloma formation and fibrosis. Furthermore, this article elucidates the role of both TGF-b/Smad and (HIF)-1a-VEGF-ING-4 signaling pathways in the development of sarcoidosis. The potential epigenetic regulation of the processes occurring in sarcoidosis by miRNA is also discussed.

Abstract

Sarcoidosis is an orphan inflammatory disorder that can virtually affect any organ or system in the body, although the lungs and lymph nodes are most frequently involved. Sarcoidosis is believed to derive from an interaction between environmental and genetic agents. Many studies emphasize a strong association between certain human leukocyte antigen (HLA) alleles and sarcoidosis susceptibility. Several new insights have allowed the further evaluation of other candidate genes with a potential function in the immunopathogenesis of sarcoidosis. This review summarizes recent advances in the identification of novel molecular markers that may play a role in different stages of disease, such as the acute phase of inflammation, granuloma formation and fibrosis. Furthermore, this article elucidates the role of both TGF-b/Smad and (HIF)-1a-VEGF-ING-4 signaling pathways in the development of sarcoidosis. The potential epigenetic regulation of the processes occurring in sarcoidosis by miRNA is also discussed.

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Keywords

sarcoidosis, molecular markers, pathogenesis

About this article
Title

Selected molecular events in the pathogenesis of sarcoidosis — recent advances

Journal

Advances in Respiratory Medicine

Issue

Vol 83, No 6 (2015)

Pages

462-475

DOI

10.5603/PiAP.2015.0076

Bibliographic record

Pneumonol Alergol Pol 2015;83(6):462-475.

Keywords

sarcoidosis
molecular markers
pathogenesis

Authors

Justyna Kiszałkiewicz
Wojciech J. Piotrowski
Ewa Brzeziańska-Lasota

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