open access

Vol 83, No 6 (2015)
ORIGINAL PAPERS
Submitted: 2015-11-10
Accepted: 2015-11-10
Get Citation

Dynamics of body composition in male patients during chronic obstructive pulmonary disease (COPD) development

Aliaksandr Eduard Makarevich, Sviatlana Lemiasheuskaya
DOI: 10.5603/PiAP.2015.0070
·
Pneumonol Alergol Pol 2015;83(6):424-430.

open access

Vol 83, No 6 (2015)
ORIGINAL PAPERS
Submitted: 2015-11-10
Accepted: 2015-11-10

Abstract

Introduction: The various distribution of fat mass (FM) and lean mass (LM) during COPD development is not yet researched.

Material and methods: 82 male patients (40–67 years) with acute exacerbation of COPD and 19 comparable healthy males (the control group) were examined by dual-energy X-ray absorptiometry. The patients were divided into 3 groups according to COPD severity: 1st — 19 (GOLD I stage); 2nd — 43 (GOLD II) and 3rd — 20 (GOLD III).

Results: The patients of 3rd group had lower indices of FM, LM, bone mineral component (BMC) vs. the control and 1st, 2nd groups. A significant increase in FM share was noted in android and gynoid regions, trunk, legs and arms in 2nd groups vs. the control with the decline of these parameters in the 3rd group below the control level. A greater proportion of FM in 1st and 2nd groups was distributed in android and trunk regions vs. the control. TNF-a and leptin levels were significantly increased by 12%, 15% 17% and by 18%, 75%, 79% respectively in 1st, 2nd, 3rd groups vs. the control, while free testosterone level was lower in these groups vs. the control (by 28%, 30% and 47% respectively; p < 0,05).

Conclusions: Body mass index (BMI) was within the control range in mild-moderate COPD patients in spite of LM, FM and BMC changes. The level of LM and BMC was decreased during COPD progression, while FM was increased in mild-moderate COPD and then it was decreased in severe COPD.

Abstract

Introduction: The various distribution of fat mass (FM) and lean mass (LM) during COPD development is not yet researched.

Material and methods: 82 male patients (40–67 years) with acute exacerbation of COPD and 19 comparable healthy males (the control group) were examined by dual-energy X-ray absorptiometry. The patients were divided into 3 groups according to COPD severity: 1st — 19 (GOLD I stage); 2nd — 43 (GOLD II) and 3rd — 20 (GOLD III).

Results: The patients of 3rd group had lower indices of FM, LM, bone mineral component (BMC) vs. the control and 1st, 2nd groups. A significant increase in FM share was noted in android and gynoid regions, trunk, legs and arms in 2nd groups vs. the control with the decline of these parameters in the 3rd group below the control level. A greater proportion of FM in 1st and 2nd groups was distributed in android and trunk regions vs. the control. TNF-a and leptin levels were significantly increased by 12%, 15% 17% and by 18%, 75%, 79% respectively in 1st, 2nd, 3rd groups vs. the control, while free testosterone level was lower in these groups vs. the control (by 28%, 30% and 47% respectively; p < 0,05).

Conclusions: Body mass index (BMI) was within the control range in mild-moderate COPD patients in spite of LM, FM and BMC changes. The level of LM and BMC was decreased during COPD progression, while FM was increased in mild-moderate COPD and then it was decreased in severe COPD.

Get Citation

Keywords

COPD, body composition, lean mass, fat mass, leptin

About this article
Title

Dynamics of body composition in male patients during chronic obstructive pulmonary disease (COPD) development

Journal

Advances in Respiratory Medicine

Issue

Vol 83, No 6 (2015)

Pages

424-430

DOI

10.5603/PiAP.2015.0070

Bibliographic record

Pneumonol Alergol Pol 2015;83(6):424-430.

Keywords

COPD
body composition
lean mass
fat mass
leptin

Authors

Aliaksandr Eduard Makarevich
Sviatlana Lemiasheuskaya

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl