open access

Vol 84, No 1 (2016)
ORIGINAL PAPERS
Published online: 2015-12-17
Submitted: 2015-08-27
Accepted: 2015-12-17
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Abnormalities in lung volumes and airflow in children with newly diagnosed connective tissue disease

Joanna Peradzyńska, Katarzyna Krenke, Anna Szylling, Beata Kołodziejczyk, Agnieszka Gazda, Lidia Rutkowska-Sak, Marek Kulus
DOI: 10.5603/PiAP.a2015.0081
·
Pneumonol Alergol Pol 2016;84(1):22-28.

open access

Vol 84, No 1 (2016)
ORIGINAL PAPERS
Published online: 2015-12-17
Submitted: 2015-08-27
Accepted: 2015-12-17

Abstract

Introduction: Connective tissue diseases (CTDs) of childhood are rare inflammatory disorders, involving various organs and tissues including respiratory system. Pulmonary involvement in patients with CTDs is uncommon but may cause functional impairment. Data on prevalence and type of lung function abnormalities in children with CTDs are scarce. Thus, the aim of this study was to asses pulmonary functional status in children with newly diagnosed CTD and follow the results after two years of the disease course.

Material and methods: There were 98 children (mean age: 13 ± 3; 76 girls), treated in Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw and 80 aged-matched, healthy controls (mean age 12.7 ± 2.4; 50 girls) included into the study. Study procedures included medical history, physical examination, chest radiograph and PFT (spirometry and whole body-plethysmography). Then, the assessment of PFT was performed after 24 months.

Results: FEV1, FEV1/FVC and MEF50 were significantly lower in CTD as compared to control group, there was no difference in FVC and TLC. The proportion of patients with abnormal lung function was significantly higher in the study group, 41 (42%) vs 9 (11%). 24-months observation didn’t reveal progression in lung function impairment.

Conclusions: Lung function impairment is relatively common in children with CTDs. Although restrictive ventilatory pattern is considered typical feature of lung involvement in CTDs, airflow limitation could also be an initial abnormality.

Abstract

Introduction: Connective tissue diseases (CTDs) of childhood are rare inflammatory disorders, involving various organs and tissues including respiratory system. Pulmonary involvement in patients with CTDs is uncommon but may cause functional impairment. Data on prevalence and type of lung function abnormalities in children with CTDs are scarce. Thus, the aim of this study was to asses pulmonary functional status in children with newly diagnosed CTD and follow the results after two years of the disease course.

Material and methods: There were 98 children (mean age: 13 ± 3; 76 girls), treated in Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw and 80 aged-matched, healthy controls (mean age 12.7 ± 2.4; 50 girls) included into the study. Study procedures included medical history, physical examination, chest radiograph and PFT (spirometry and whole body-plethysmography). Then, the assessment of PFT was performed after 24 months.

Results: FEV1, FEV1/FVC and MEF50 were significantly lower in CTD as compared to control group, there was no difference in FVC and TLC. The proportion of patients with abnormal lung function was significantly higher in the study group, 41 (42%) vs 9 (11%). 24-months observation didn’t reveal progression in lung function impairment.

Conclusions: Lung function impairment is relatively common in children with CTDs. Although restrictive ventilatory pattern is considered typical feature of lung involvement in CTDs, airflow limitation could also be an initial abnormality.

Get Citation

Keywords

lung function tests, rheumatic diseases of childhood, pulmonary involvement

About this article
Title

Abnormalities in lung volumes and airflow in children with newly diagnosed connective tissue disease

Journal

Advances in Respiratory Medicine

Issue

Vol 84, No 1 (2016)

Pages

22-28

Published online

2015-12-17

DOI

10.5603/PiAP.a2015.0081

Bibliographic record

Pneumonol Alergol Pol 2016;84(1):22-28.

Keywords

lung function tests
rheumatic diseases of childhood
pulmonary involvement

Authors

Joanna Peradzyńska
Katarzyna Krenke
Anna Szylling
Beata Kołodziejczyk
Agnieszka Gazda
Lidia Rutkowska-Sak
Marek Kulus

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