open access

Vol 83, No 4 (2015)
REVIEWS
Submitted: 2015-07-09
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The statement of the Polish Society of Allergology experts on the treatment of difficult-to-treat asthma

Anna Bodzenta-Łukaszyk, Andrzej M. Fal, Ewa Jassem, Marek L. Kowalski, Piotr Kuna, Maciej Kupczyk
DOI: 10.5603/PiAP.2015.0052
·
Pubmed: 26166794
·
Pneumonol Alergol Pol 2015;83(4):324-334.

open access

Vol 83, No 4 (2015)
REVIEWS
Submitted: 2015-07-09

Abstract

The main objective of asthma treatment is to control symptoms of the disease; however, despite the availability of guidelines and many groups of medications, the degree of control of this condition is insufficient. In difficult-to-treat asthma, the optimal control cannot be achieved due to reasons independent of the disease. Factors worsening asthma control include: inadequate treatment plan (low therapy adherence and compliance), inappropriate inhalation technique, insufficient symptom control using the available classes of medications, incomplete response to treatment (non-responders, steroid-resistance), incorrect diagnosis of asthma or comorbidities, and environmental factors. In order to achieve the optimal asthma control, it is recommended to: take therapeutic decisions with the patient, assess the probability of non-compliance, perform detailed diagnostics and initiate treatment of concomitant diseases, carry out differential diagnosis of conditions mimicking asthma, educate the patient as to the inhalation technique and check it, eliminate unfavourable environmental factors, and modify current treatment. New treatment options for patients with asthma include: ultra-long-acting beta2-agonists, long-acting muscarine receptor antagonists (LAMA), monoclonal antibodies, and non-pharmacological interventions. The only LAMA approved for treatment of asthma is tiotropium bromide. The analyses performed demonstrated a high efficacy of tiotropium in terms of improved lung function parameters and prolonged time to the first asthma exacerbation. It is recommended as an add-on therapy at asthma treatment steps 4 and 5 according to GINA (Global Initiative for Asthma) 2014. The optimal asthma control is important from the medical as well as the economical point of view.

Abstract

The main objective of asthma treatment is to control symptoms of the disease; however, despite the availability of guidelines and many groups of medications, the degree of control of this condition is insufficient. In difficult-to-treat asthma, the optimal control cannot be achieved due to reasons independent of the disease. Factors worsening asthma control include: inadequate treatment plan (low therapy adherence and compliance), inappropriate inhalation technique, insufficient symptom control using the available classes of medications, incomplete response to treatment (non-responders, steroid-resistance), incorrect diagnosis of asthma or comorbidities, and environmental factors. In order to achieve the optimal asthma control, it is recommended to: take therapeutic decisions with the patient, assess the probability of non-compliance, perform detailed diagnostics and initiate treatment of concomitant diseases, carry out differential diagnosis of conditions mimicking asthma, educate the patient as to the inhalation technique and check it, eliminate unfavourable environmental factors, and modify current treatment. New treatment options for patients with asthma include: ultra-long-acting beta2-agonists, long-acting muscarine receptor antagonists (LAMA), monoclonal antibodies, and non-pharmacological interventions. The only LAMA approved for treatment of asthma is tiotropium bromide. The analyses performed demonstrated a high efficacy of tiotropium in terms of improved lung function parameters and prolonged time to the first asthma exacerbation. It is recommended as an add-on therapy at asthma treatment steps 4 and 5 according to GINA (Global Initiative for Asthma) 2014. The optimal asthma control is important from the medical as well as the economical point of view.

Get Citation

Keywords

asthma, bronchodilators, asthma control, difficult-to-treat asthma

About this article
Title

The statement of the Polish Society of Allergology experts on the treatment of difficult-to-treat asthma

Journal

Advances in Respiratory Medicine

Issue

Vol 83, No 4 (2015)

Pages

324-334

DOI

10.5603/PiAP.2015.0052

Pubmed

26166794

Bibliographic record

Pneumonol Alergol Pol 2015;83(4):324-334.

Keywords

asthma
bronchodilators
asthma control
difficult-to-treat asthma

Authors

Anna Bodzenta-Łukaszyk
Andrzej M. Fal
Ewa Jassem
Marek L. Kowalski
Piotr Kuna
Maciej Kupczyk

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