open access

Vol 84, No 1 (2016)
REVIEWS
Published online: 2015-12-23
Submitted: 2015-05-26
Accepted: 2015-12-22
Get Citation

Pulmonary arterial hypertension: a current review of pharmacological management

Sonu Sahni, Marcin Ojrzanowski, Sebastian Majewski, Arunabh Talwar
DOI: 10.5603/PiAP.a2015.0084
·
Pneumonol Alergol Pol 2016;84(1):47-61.

open access

Vol 84, No 1 (2016)
REVIEWS
Published online: 2015-12-23
Submitted: 2015-05-26
Accepted: 2015-12-22

Abstract

Pulmonary hypertension (PHTN) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventricular failure and death. At present there is no cure for pulmonary arterial hypertension (PAH); however over the past decade targeted pharmaceutical options have become available for the treatment of PAH. Prior to evaluation for therapeutic options a definitive diagnosis of pulmonary arterial hypertension must be made via comprehensive physical exam and definitive diagnostic testing. Screening test of choice remains echocardiography and gold standard for definitive diagnosis is right heart catheterization. Once the establishment of a diagnosis of PAH is made therapeutic options may be a possibility based on a diagnostic algorithm and disease severity of the PAH patient. There are different classes of medications available with different mechanisms of actions which net a vasodilatory effect and improve exercise tolerance, quality of life as well and survival.

Abstract

Pulmonary hypertension (PHTN) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventricular failure and death. At present there is no cure for pulmonary arterial hypertension (PAH); however over the past decade targeted pharmaceutical options have become available for the treatment of PAH. Prior to evaluation for therapeutic options a definitive diagnosis of pulmonary arterial hypertension must be made via comprehensive physical exam and definitive diagnostic testing. Screening test of choice remains echocardiography and gold standard for definitive diagnosis is right heart catheterization. Once the establishment of a diagnosis of PAH is made therapeutic options may be a possibility based on a diagnostic algorithm and disease severity of the PAH patient. There are different classes of medications available with different mechanisms of actions which net a vasodilatory effect and improve exercise tolerance, quality of life as well and survival.

Get Citation

Keywords

pulmonary arterial hypertension, phosphodiesterase type 5 inhibitors, endothelin receptor antagonist, prostacyclin analogues, right heart catheterization

About this article
Title

Pulmonary arterial hypertension: a current review of pharmacological management

Journal

Advances in Respiratory Medicine

Issue

Vol 84, No 1 (2016)

Pages

47-61

Published online

2015-12-23

DOI

10.5603/PiAP.a2015.0084

Bibliographic record

Pneumonol Alergol Pol 2016;84(1):47-61.

Keywords

pulmonary arterial hypertension
phosphodiesterase type 5 inhibitors
endothelin receptor antagonist
prostacyclin analogues
right heart catheterization

Authors

Sonu Sahni
Marcin Ojrzanowski
Sebastian Majewski
Arunabh Talwar

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