open access

Vol 83, No 3 (2015)
CASE REPORTS
Submitted: 2015-04-30
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Synchronous two distinct neuroendocrine lung cancer lesions

Mateusz Rydel, Damian Czyżewski, Katarzyna Stęplewska, Agnieszka Zygo, Mariusz Adamek
DOI: 10.5603/PiAP.2015.0034
·
Pneumonol Alergol Pol 2015;83(3):212-215.

open access

Vol 83, No 3 (2015)
CASE REPORTS
Submitted: 2015-04-30

Abstract

The synchronous primary lung tumors is a rare condition and presented patient is the first reported case of simultaneous two distinct neuroendocrine lung cancer lesions in the same lobe. We present the case of a 55-year-old woman with synchronous two distinct neuroendocrine lung cancer lesions in the right upper lobe. Initially she showed no signs or symptoms related to lung lesions and was admitted to Thoracic Surgery Ward for the investigation of two oval, solitary pulmonary nodules (11 and 19 mm in diameter) detected on a chest X-ray performed three months earlier. The radiological imaging showed a variability of growth of both lesions (smaller tumor has enlarged while the larger one remained unchanged). After the CT-guided lung biopsy, patient underwent right upper lobectomy. Histological examination revealed a small cell carcinoma in one of the tumors and a large cell neuroendocrine carcinoma in the other one. The patient was discharged in good condition and lung inflation in chest X-ray and qualified for adjuvant chemotherapy with a combination of cisplatin and etoposide and the prophylactic cranial irradiation. Very important issues, having impact on outcome of patients with multiple lung tumours is differentiation whether the lesions are metastases or synchronous primary lung tumors and the optimal management of these patients.

Abstract

The synchronous primary lung tumors is a rare condition and presented patient is the first reported case of simultaneous two distinct neuroendocrine lung cancer lesions in the same lobe. We present the case of a 55-year-old woman with synchronous two distinct neuroendocrine lung cancer lesions in the right upper lobe. Initially she showed no signs or symptoms related to lung lesions and was admitted to Thoracic Surgery Ward for the investigation of two oval, solitary pulmonary nodules (11 and 19 mm in diameter) detected on a chest X-ray performed three months earlier. The radiological imaging showed a variability of growth of both lesions (smaller tumor has enlarged while the larger one remained unchanged). After the CT-guided lung biopsy, patient underwent right upper lobectomy. Histological examination revealed a small cell carcinoma in one of the tumors and a large cell neuroendocrine carcinoma in the other one. The patient was discharged in good condition and lung inflation in chest X-ray and qualified for adjuvant chemotherapy with a combination of cisplatin and etoposide and the prophylactic cranial irradiation. Very important issues, having impact on outcome of patients with multiple lung tumours is differentiation whether the lesions are metastases or synchronous primary lung tumors and the optimal management of these patients.

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Keywords

synchronous primary lung cancer, large cell neuroendocrine carcinoma, small cell carcinoma

About this article
Title

Synchronous two distinct neuroendocrine lung cancer lesions

Journal

Advances in Respiratory Medicine

Issue

Vol 83, No 3 (2015)

Pages

212-215

DOI

10.5603/PiAP.2015.0034

Bibliographic record

Pneumonol Alergol Pol 2015;83(3):212-215.

Keywords

synchronous primary lung cancer
large cell neuroendocrine carcinoma
small cell carcinoma

Authors

Mateusz Rydel
Damian Czyżewski
Katarzyna Stęplewska
Agnieszka Zygo
Mariusz Adamek

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