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Leflunomide-induced acute interstitial pneumonia in a patient treated for rheumatoid arthritis
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Abstract
Leflunomide is a disease-modifying anti-rheumatic drug that is used in patients with rheumatoid arthritis (RA), who do not respond well to standard RA treatment. Leflunomide therapy may, however, be related with significant pulmonary complications in predisposed individuals. We present a patient with RA treated with leflunomide, in whom leflunomide lung injury had a fatal outcome. Potential risk factors for pulmonary complications of leflunomide treatment and the management of patients with leflunomide lung injury are discussed.
Abstract
Leflunomide is a disease-modifying anti-rheumatic drug that is used in patients with rheumatoid arthritis (RA), who do not respond well to standard RA treatment. Leflunomide therapy may, however, be related with significant pulmonary complications in predisposed individuals. We present a patient with RA treated with leflunomide, in whom leflunomide lung injury had a fatal outcome. Potential risk factors for pulmonary complications of leflunomide treatment and the management of patients with leflunomide lung injury are discussed.
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Keywords
interstitial pneumonia, rheumatoid arthritis, leflunomide
About this articleTitle
Leflunomide-induced acute interstitial pneumonia in a patient treated for rheumatoid arthritis
Journal
Advances in Respiratory Medicine
Issue
Article type
Case report
Pages
50-54
Page views
2105
Article views/downloads
2306
DOI
10.5603/PiAP.2015.0007
Pubmed
Bibliographic record
Pneumonol Alergol Pol 2015;83(1):50-54.
Keywords
interstitial pneumonia
rheumatoid arthritis
leflunomide
Authors
Marta Maskey-Warzęchowska
Krzysztof Karwat
Benedykt Szczepankiewicz
Renata Langfort
Małgorzata Szołkowska
Ryszarda Chazan
