open access

Vol 82, No 5 (2014)
GUIDELINES
Submitted: 2014-08-18
Accepted: 2014-08-18
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Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies

Paweł Krawczyk, Joanna Chorostowska-Wynimko, Rafał Dziadziuszko, Jacek Jassem, Maciej Krzakowski, Renata Langfort, Elżbieta Puacz, Bartosz Wasąg, Kamila Wojas-Krawczyk
DOI: 10.5603/PiAP.2014.0057
·
Pneumonol Alergol Pol 2014;82(5):437-444.

open access

Vol 82, No 5 (2014)
GUIDELINES
Submitted: 2014-08-18
Accepted: 2014-08-18

Abstract

Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.

Abstract

Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.

Get Citation

Keywords

non-small-cell lung cancer, EGFR gene mutations, ALK gene rearrangement, genetic diagnostic tests

About this article
Title

Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies

Journal

Advances in Respiratory Medicine

Issue

Vol 82, No 5 (2014)

Pages

437-444

DOI

10.5603/PiAP.2014.0057

Bibliographic record

Pneumonol Alergol Pol 2014;82(5):437-444.

Keywords

non-small-cell lung cancer
EGFR gene mutations
ALK gene rearrangement
genetic diagnostic tests

Authors

Paweł Krawczyk
Joanna Chorostowska-Wynimko
Rafał Dziadziuszko
Jacek Jassem
Maciej Krzakowski
Renata Langfort
Elżbieta Puacz
Bartosz Wasąg
Kamila Wojas-Krawczyk

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