open access

Vol 82, No 1 (2014)
CASE REPORTS
Submitted: 2013-12-20
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Interferon-Gamma Release Assays in the diagnosis of latent tuberculosis infection in clinical situations

Dagmara Borkowska, Elżbieta Radzikowska, Jolanta Załęska, Jerzy Ziołkowski, Magdalena Klatt, Zofia Zwolska, Ewa Augustynowicz-Kopeć, Kazimierz Roszkowski-Śliż
DOI: 10.5603/PiAP.2014.0007
·
Pneumonol Alergol Pol 2014;82(1):39-45.

open access

Vol 82, No 1 (2014)
CASE REPORTS
Submitted: 2013-12-20

Abstract

Until recently, the basic test to identify latent tuberculosis infection (LTBI) was the tuberculin skin test, despite its limitations in the form of low sensitivity and specificity. Currently, Interferon Gamma Release Assays from peripheral blood are used for a rapid diagnosis of LTBI and measurement of the interferon gamma (IFN-g) levels secreted by specific T cells stimulated with Mycobacterium tuberculosis antigens. Detection of LTBI is important in the control of people potentially at risk of TB disease, such as people remaining in close contact with BK (+) tb patient and for patients evaluated for biological treatment. The paper presents the value of IGRA in three selected clinical situations: in two cases of latent tuberculosis infection and in one case of active tuberculosis.

Abstract

Until recently, the basic test to identify latent tuberculosis infection (LTBI) was the tuberculin skin test, despite its limitations in the form of low sensitivity and specificity. Currently, Interferon Gamma Release Assays from peripheral blood are used for a rapid diagnosis of LTBI and measurement of the interferon gamma (IFN-g) levels secreted by specific T cells stimulated with Mycobacterium tuberculosis antigens. Detection of LTBI is important in the control of people potentially at risk of TB disease, such as people remaining in close contact with BK (+) tb patient and for patients evaluated for biological treatment. The paper presents the value of IGRA in three selected clinical situations: in two cases of latent tuberculosis infection and in one case of active tuberculosis.

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Keywords

latent tuberculosis infection, IGRA-Interferon-Gamma Release Assay, tuberculin skin test, tuberculosis

About this article
Title

Interferon-Gamma Release Assays in the diagnosis of latent tuberculosis infection in clinical situations

Journal

Advances in Respiratory Medicine

Issue

Vol 82, No 1 (2014)

Pages

39-45

DOI

10.5603/PiAP.2014.0007

Bibliographic record

Pneumonol Alergol Pol 2014;82(1):39-45.

Keywords

latent tuberculosis infection
IGRA-Interferon-Gamma Release Assay
tuberculin skin test
tuberculosis

Authors

Dagmara Borkowska
Elżbieta Radzikowska
Jolanta Załęska
Jerzy Ziołkowski
Magdalena Klatt
Zofia Zwolska
Ewa Augustynowicz-Kopeć
Kazimierz Roszkowski-Śliż

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