open access

Vol 81, No 5 (2013)
CASE REPORTS
Submitted: 2013-08-22
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Acute lupus pneumonitis — case report and literature review

Małgorzata H. Starczewska, Liliana Wawrzyńska, Lucyna Opoka, Grzegorz Małek, Monika Wieliczko, Joanna Matuszkiewicz-Rowińska, Monika Szturmowicz
Pneumonol Alergol Pol 2013;81(5):460-467.

open access

Vol 81, No 5 (2013)
CASE REPORTS
Submitted: 2013-08-22

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that is characterized by its chronic course and the involvement of many organs and systems. The most common abnormality in the respiratory system of SLE patients is lupus pleuritis. Less common is parenchymal involvement, which may present as acute lupus pneumonitis (ALP) or chronic interstitial lung disease. Other possible pulmonary manifestations of SLE include pulmonary embolism, diffuse alveolar haemorrhage, acute reversible hypoxaemia, and shrinking lung syndrome. We present the case report of a young woman with previously diagnosed membranous glomerulonephritis with nephrotic syndrome and antiphospholipid syndrome, who was admitted with marked of shortness of breath. The diagnostic process, including imaging studies and laboratory tests, enabled us to confirm a diagnosis of ALP. After initiation of treatment with high doses of methyloprednisolone, nearly complete remission of pulmonary changes was observed. We also perform a literature review regarding acute lupus pneumonitis.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that is characterized by its chronic course and the involvement of many organs and systems. The most common abnormality in the respiratory system of SLE patients is lupus pleuritis. Less common is parenchymal involvement, which may present as acute lupus pneumonitis (ALP) or chronic interstitial lung disease. Other possible pulmonary manifestations of SLE include pulmonary embolism, diffuse alveolar haemorrhage, acute reversible hypoxaemia, and shrinking lung syndrome. We present the case report of a young woman with previously diagnosed membranous glomerulonephritis with nephrotic syndrome and antiphospholipid syndrome, who was admitted with marked of shortness of breath. The diagnostic process, including imaging studies and laboratory tests, enabled us to confirm a diagnosis of ALP. After initiation of treatment with high doses of methyloprednisolone, nearly complete remission of pulmonary changes was observed. We also perform a literature review regarding acute lupus pneumonitis.

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Keywords

systemic lupus erythematosus, acute lupus pneumonitis, respiratory failure, computed tomography

About this article
Title

Acute lupus pneumonitis — case report and literature review

Journal

Advances in Respiratory Medicine

Issue

Vol 81, No 5 (2013)

Pages

460-467

Bibliographic record

Pneumonol Alergol Pol 2013;81(5):460-467.

Keywords

systemic lupus erythematosus
acute lupus pneumonitis
respiratory failure
computed tomography

Authors

Małgorzata H. Starczewska
Liliana Wawrzyńska
Lucyna Opoka
Grzegorz Małek
Monika Wieliczko
Joanna Matuszkiewicz-Rowińska
Monika Szturmowicz

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