Vol 72, No 5-6 (2004)
Research paper
Published online: 2008-02-18
Submitted: 2013-02-22
Level of mannose-biding lectin (MBL) in patients with tuberculosis
Agnieszka Bonar, Magdalena Chmiela, Barbara Różalska
Pneumonol Alergol Pol 2004;72(5-6):201-205.
Vol 72, No 5-6 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
Abstract
Mannose-binding lectin (MBL) constitutes an important element in innate immune response against invading microorganisms. On the other hand, it has also been suggested that MBL, due their opsonic activity, might facilitate the uptake of certain intracellular pathogens. The aim of this study was to investigate whether MBL plays a role in tuberculosis. MBL serum concentration was determined in 68 patients with tuberculosis (TB), 30 patients with non-TB lung diseases and in 64 healthy controls. Serum MBL level was tested by an ELISA test with S. cerevisiae
mannan -coated microtiter plates. Generaly, TB patients had significantly higher MBL levels than both control groups, and in TB group percentage of individuals with highest MBL level was significantlyhigher(39.7%).Theseresults indicate that high levels of MBL may be involved in the pathogenesis of tuberculosis and to be a relative disadvantage in mycobacterial infection.
Abstract
Mannose-binding lectin (MBL) constitutes an important element in innate immune response against invading microorganisms. On the other hand, it has also been suggested that MBL, due their opsonic activity, might facilitate the uptake of certain intracellular pathogens. The aim of this study was to investigate whether MBL plays a role in tuberculosis. MBL serum concentration was determined in 68 patients with tuberculosis (TB), 30 patients with non-TB lung diseases and in 64 healthy controls. Serum MBL level was tested by an ELISA test with S. cerevisiae
mannan -coated microtiter plates. Generaly, TB patients had significantly higher MBL levels than both control groups, and in TB group percentage of individuals with highest MBL level was significantlyhigher(39.7%).Theseresults indicate that high levels of MBL may be involved in the pathogenesis of tuberculosis and to be a relative disadvantage in mycobacterial infection.
Keywords
collectins; mannose-binding lectin (MBL); ELISA; tuberculosis
Title
Level of mannose-biding lectin (MBL) in patients with tuberculosis
Journal
Advances in Respiratory Medicine
Issue
Vol 72, No 5-6 (2004)
Article type
Research paper
Pages
201-205
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2004;72(5-6):201-205.
Keywords
collectins
mannose-binding lectin (MBL)
ELISA
tuberculosis
Authors
Agnieszka Bonar
Magdalena Chmiela
Barbara Różalska