Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Advances in Respiratory Medicine
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Author statement Editorial Policy and Information for Authors

open access

Vol 72, No 5-6 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
View PDF (polish) Download PDF file
Get Citation

Level of mannose-biding lectin (MBL) in patients with tuberculosis

Agnieszka Bonar, Magdalena Chmiela, Barbara Różalska
Pneumonol Alergol Pol 2004;72(5-6):201-205.

open access

Vol 72, No 5-6 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Mannose-binding lectin (MBL) constitutes an important element in innate immune response against invading microorganisms. On the other hand, it has also been suggested that MBL, due their opsonic activity, might facilitate the uptake of certain intracellular pathogens. The aim of this study was to investigate whether MBL plays a role in tuberculosis. MBL serum concentration was determined in 68 patients with tuberculosis (TB), 30 patients with non-TB lung diseases and in 64 healthy controls. Serum MBL level was tested by an ELISA test with S. cerevisiae mannan -coated microtiter plates. Generaly, TB patients had significantly higher MBL levels than both control groups, and in TB group percentage of individuals with highest MBL level was significantlyhigher(39.7%).Theseresults indicate that high levels of MBL may be involved in the pathogenesis of tuberculosis and to be a relative disadvantage in mycobacterial infection.

Abstract

Mannose-binding lectin (MBL) constitutes an important element in innate immune response against invading microorganisms. On the other hand, it has also been suggested that MBL, due their opsonic activity, might facilitate the uptake of certain intracellular pathogens. The aim of this study was to investigate whether MBL plays a role in tuberculosis. MBL serum concentration was determined in 68 patients with tuberculosis (TB), 30 patients with non-TB lung diseases and in 64 healthy controls. Serum MBL level was tested by an ELISA test with S. cerevisiae mannan -coated microtiter plates. Generaly, TB patients had significantly higher MBL levels than both control groups, and in TB group percentage of individuals with highest MBL level was significantlyhigher(39.7%).Theseresults indicate that high levels of MBL may be involved in the pathogenesis of tuberculosis and to be a relative disadvantage in mycobacterial infection.

Full Text:

View PDF (polish) Download PDF file
Get Citation

Keywords

collectins; mannose-binding lectin (MBL); ELISA; tuberculosis

About this article
Title

Level of mannose-biding lectin (MBL) in patients with tuberculosis

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 5-6 (2004)

Pages

201-205

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(5-6):201-205.

Keywords

collectins
mannose-binding lectin (MBL)
ELISA
tuberculosis

Authors

Agnieszka Bonar
Magdalena Chmiela
Barbara Różalska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl