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open access

Vol 73, No 1-2 (2005)
CASE REPORTS
Published online: 2008-02-18
Submitted: 2013-02-22
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Recurrent alveolar hemorrhage in the course of Goodpasture's syndrome

Dariusz Gawryluk, Teresa Bączkowska, Joanna Pazik, Elżbieta Wiatr, Jacek Pawłowski
Pneumonol Alergol Pol 2005;73(1-2):79-84.

open access

Vol 73, No 1-2 (2005)
CASE REPORTS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

We describe the case of 24-years old man, smoking up to 60 cigarettes daily, with rapidly progressive crescentic glomerulonephritis in the course of Goodpasture’s syndrome. The disease was initially presented with recurrent diffuse pulmonary hemorrhage with normal renal function and moderate proteinuria and haematuria on urinalysis lasting 2 months. Immunologic tests for ANCA and anti-GBM Ab were negative until the patient’s renal function rapidly deteriorated during next 3 weeks. At the time of the diagnosis patient presented with renal in sufficiency with oliguria requiring hemodialysis but with out pulmonary hemorrhage. Renal biopsy showed cellular crescents in all glomeruli with linear deposition of IgG along the GBM. Repeated testing showed anti-GBM Ab. The patient received pulse cyclophosphamide, and pulse methylprednisolone continued by oral prednisone, and consecutive plasma exchange treatment but remained oliguric after 3 weeks of the treatment. The case confirmthatin Goodpasture's syndrome even several days’ delay in diagnosis and treatment has a strongly negative impact on outcome.
Pneumonol. Alergol. Pol. 2005, 73, 79-84

Abstract

We describe the case of 24-years old man, smoking up to 60 cigarettes daily, with rapidly progressive crescentic glomerulonephritis in the course of Goodpasture’s syndrome. The disease was initially presented with recurrent diffuse pulmonary hemorrhage with normal renal function and moderate proteinuria and haematuria on urinalysis lasting 2 months. Immunologic tests for ANCA and anti-GBM Ab were negative until the patient’s renal function rapidly deteriorated during next 3 weeks. At the time of the diagnosis patient presented with renal in sufficiency with oliguria requiring hemodialysis but with out pulmonary hemorrhage. Renal biopsy showed cellular crescents in all glomeruli with linear deposition of IgG along the GBM. Repeated testing showed anti-GBM Ab. The patient received pulse cyclophosphamide, and pulse methylprednisolone continued by oral prednisone, and consecutive plasma exchange treatment but remained oliguric after 3 weeks of the treatment. The case confirmthatin Goodpasture's syndrome even several days’ delay in diagnosis and treatment has a strongly negative impact on outcome.
Pneumonol. Alergol. Pol. 2005, 73, 79-84

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Keywords

pulmonary-renal syndrome; diffuse alveolar hemorrhage; rapidly progeressive glomerulonephritis; Goodpasture’s syndrome

About this article
Title

Recurrent alveolar hemorrhage in the course of Goodpasture's syndrome

Journal

Advances in Respiratory Medicine

Issue

Vol 73, No 1-2 (2005)

Pages

79-84

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2005;73(1-2):79-84.

Keywords

pulmonary-renal syndrome
diffuse alveolar hemorrhage
rapidly progeressive glomerulonephritis
Goodpasture’s syndrome

Authors

Dariusz Gawryluk
Teresa Bączkowska
Joanna Pazik
Elżbieta Wiatr
Jacek Pawłowski

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