open access

Vol 73, No 1-2 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Time factor in radiotherapy and chemiotherapy for small cell lung cancer

Elżbieta Nowara, Rafał Suwiński
Pneumonol Alergol Pol 2005;73(1-2):23-31.

open access

Vol 73, No 1-2 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Introduction: Selection of treatment schedule in patients with small cell lung cancer (SCLC) appears to be a subject of controversies. One of the most controversial issue is influenceofplannedandunplanned gaps in radiotherapy and chemotherapy on efficacyofradicaltreatmentofpatientswithlimited disease. These controversies created the basis for current research.
Material: 245 patients with LD-SCLC treated in Cancer Center in Gliwice between 1989 and 2001 were included in the present analysis. There were 60 women and 185 men, median age 58 years; All these patients were in good general condition. Cisplatine based chemotherapy and total radiation dose higher than 30Gy were used in all of them.
Methods: Overall survival was analyzed using Kaplan-Meier analysis. The variables potentially influencingoverallsurvivalincludingdose-intensityofchemotherapyandradiotherapywereanalyzedusing multivariate Cox regression model.
Results: 3-year actuarial overall survival in a whole group of patients was 10 percent. The following variables had negative influenceonoverallsurvivalinmultivariate Cox model:performance status ZUBROD higher than 0 (p

Abstract

Introduction: Selection of treatment schedule in patients with small cell lung cancer (SCLC) appears to be a subject of controversies. One of the most controversial issue is influenceofplannedandunplanned gaps in radiotherapy and chemotherapy on efficacyofradicaltreatmentofpatientswithlimited disease. These controversies created the basis for current research.
Material: 245 patients with LD-SCLC treated in Cancer Center in Gliwice between 1989 and 2001 were included in the present analysis. There were 60 women and 185 men, median age 58 years; All these patients were in good general condition. Cisplatine based chemotherapy and total radiation dose higher than 30Gy were used in all of them.
Methods: Overall survival was analyzed using Kaplan-Meier analysis. The variables potentially influencingoverallsurvivalincludingdose-intensityofchemotherapyandradiotherapywereanalyzedusing multivariate Cox regression model.
Results: 3-year actuarial overall survival in a whole group of patients was 10 percent. The following variables had negative influenceonoverallsurvivalinmultivariate Cox model:performance status ZUBROD higher than 0 (p
Get Citation

Keywords

small cell lung cancer; chemoradiotherapy; interruptions in chemotherapy and radiotherapy; dose intensity of chemotherapy; dose intensity of radiotherapy

About this article
Title

Time factor in radiotherapy and chemiotherapy for small cell lung cancer

Journal

Advances in Respiratory Medicine

Issue

Vol 73, No 1-2 (2005)

Pages

23-31

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2005;73(1-2):23-31.

Keywords

small cell lung cancer
chemoradiotherapy
interruptions in chemotherapy and radiotherapy
dose intensity of chemotherapy
dose intensity of radiotherapy

Authors

Elżbieta Nowara
Rafał Suwiński

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