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open access

Vol 73, No 1-2 (2005)
Research paper
Published online: 2008-02-18
Submitted: 2013-02-22
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Microbiological and molecular analysis of Mycobabacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis

Szymon Dworniczak, Grzegorz Niepsuj, Leszek Konofalski, Robert D. Wojtyczka, Danuta Idzik, Maria Kepa, Zenobia Wydmuch, Jerzy Pacha, Wanda Mazur, Jolanta Kieda-Szurkowska, Aleksandra Nieroda-Müller, Jerzy Kozielski
Pneumonol Alergol Pol 2005;73(1-2):4-11.

open access

Vol 73, No 1-2 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

The aim of the study was to perform microbiological and molecular analysis of Mycobacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis originating from two different regions of Silesia voivodship in 2000 year. One of 135 strains subjected to the study lacked IS6110 insertion sequence. Its belonging to Mycobacterium tuberculosis complex was confirmedbypositivetestforspecificgyrBgenesequence. Strainresistanceanalysisrevealedthat in previously diagnosed patients resistance to streptomycin (16,2%) was more frequent than other. In contrast to never treated patients group where the prevalence of resistance to isoniazid was the most frequent (4,5%). In both group of patients resistance to rifampin or ethambutol was not detected. The multidrug resistance strains (4,6%) were detected only in the previously diagnosed group.
Combined analysis of microbiological, epidemiological and molecular data are essential for creation of functional registry of patients infected with resistant Mycobacteria, giving the possibility of surveillance of drug resistant tuberculosis in populations.
Pneumonol. Alergol. Pol. 2005, 73, 4-11.

Abstract

The aim of the study was to perform microbiological and molecular analysis of Mycobacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis originating from two different regions of Silesia voivodship in 2000 year. One of 135 strains subjected to the study lacked IS6110 insertion sequence. Its belonging to Mycobacterium tuberculosis complex was confirmedbypositivetestforspecificgyrBgenesequence. Strainresistanceanalysisrevealedthat in previously diagnosed patients resistance to streptomycin (16,2%) was more frequent than other. In contrast to never treated patients group where the prevalence of resistance to isoniazid was the most frequent (4,5%). In both group of patients resistance to rifampin or ethambutol was not detected. The multidrug resistance strains (4,6%) were detected only in the previously diagnosed group.
Combined analysis of microbiological, epidemiological and molecular data are essential for creation of functional registry of patients infected with resistant Mycobacteria, giving the possibility of surveillance of drug resistant tuberculosis in populations.
Pneumonol. Alergol. Pol. 2005, 73, 4-11.

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Keywords

pulmonary tuberculosis; drug resistance; MDR

About this article
Title

Microbiological and molecular analysis of Mycobabacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis

Journal

Advances in Respiratory Medicine

Issue

Vol 73, No 1-2 (2005)

Article type

Research paper

Pages

4-11

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2005;73(1-2):4-11.

Keywords

pulmonary tuberculosis
drug resistance
MDR

Authors

Szymon Dworniczak
Grzegorz Niepsuj
Leszek Konofalski
Robert D. Wojtyczka
Danuta Idzik
Maria Kepa
Zenobia Wydmuch
Jerzy Pacha
Wanda Mazur
Jolanta Kieda-Szurkowska
Aleksandra Nieroda-Müller
Jerzy Kozielski

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