Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Advances in Respiratory Medicine
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Author statement Editorial Policy and Information for Authors

open access

Vol 73, No 1-2 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
View PDF (polish) Download PDF file
Get Citation

Microbiological and molecular analysis of Mycobabacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis

Szymon Dworniczak, Grzegorz Niepsuj, Leszek Konofalski, Robert D. Wojtyczka, Danuta Idzik, Maria Kepa, Zenobia Wydmuch, Jerzy Pacha, Wanda Mazur, Jolanta Kieda-Szurkowska, Aleksandra Nieroda-Müller, Jerzy Kozielski
Pneumonol Alergol Pol 2005;73(1-2):4-11.

open access

Vol 73, No 1-2 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

The aim of the study was to perform microbiological and molecular analysis of Mycobacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis originating from two different regions of Silesia voivodship in 2000 year. One of 135 strains subjected to the study lacked IS6110 insertion sequence. Its belonging to Mycobacterium tuberculosis complex was confirmedbypositivetestforspecificgyrBgenesequence. Strainresistanceanalysisrevealedthat in previously diagnosed patients resistance to streptomycin (16,2%) was more frequent than other. In contrast to never treated patients group where the prevalence of resistance to isoniazid was the most frequent (4,5%). In both group of patients resistance to rifampin or ethambutol was not detected. The multidrug resistance strains (4,6%) were detected only in the previously diagnosed group.
Combined analysis of microbiological, epidemiological and molecular data are essential for creation of functional registry of patients infected with resistant Mycobacteria, giving the possibility of surveillance of drug resistant tuberculosis in populations.
Pneumonol. Alergol. Pol. 2005, 73, 4-11.

Abstract

The aim of the study was to perform microbiological and molecular analysis of Mycobacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis originating from two different regions of Silesia voivodship in 2000 year. One of 135 strains subjected to the study lacked IS6110 insertion sequence. Its belonging to Mycobacterium tuberculosis complex was confirmedbypositivetestforspecificgyrBgenesequence. Strainresistanceanalysisrevealedthat in previously diagnosed patients resistance to streptomycin (16,2%) was more frequent than other. In contrast to never treated patients group where the prevalence of resistance to isoniazid was the most frequent (4,5%). In both group of patients resistance to rifampin or ethambutol was not detected. The multidrug resistance strains (4,6%) were detected only in the previously diagnosed group.
Combined analysis of microbiological, epidemiological and molecular data are essential for creation of functional registry of patients infected with resistant Mycobacteria, giving the possibility of surveillance of drug resistant tuberculosis in populations.
Pneumonol. Alergol. Pol. 2005, 73, 4-11.

Full Text:

View PDF (polish) Download PDF file
Get Citation

Keywords

pulmonary tuberculosis; drug resistance; MDR

About this article
Title

Microbiological and molecular analysis of Mycobabacterium tuberculosis complex strains isolated from patients with pulmonary tuberculosis

Journal

Advances in Respiratory Medicine

Issue

Vol 73, No 1-2 (2005)

Pages

4-11

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2005;73(1-2):4-11.

Keywords

pulmonary tuberculosis
drug resistance
MDR

Authors

Szymon Dworniczak
Grzegorz Niepsuj
Leszek Konofalski
Robert D. Wojtyczka
Danuta Idzik
Maria Kepa
Zenobia Wydmuch
Jerzy Pacha
Wanda Mazur
Jolanta Kieda-Szurkowska
Aleksandra Nieroda-Müller
Jerzy Kozielski

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl