open access

Vol 73, No 3-4 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Is the microscopic morphology of thymoma of clinical significance?

Małgorzata Szołkowska, Renata Langfort, Kazimierz Roszkowski-Śliż
Pneumonol Alergol Pol 2005;73(3-4):153-159.

open access

Vol 73, No 3-4 (2005)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Thymomas are rare mediastinal tumors that have heterogeneous microscopic morphology and uncertain outcome.
AIM: The aim of the study was to evaluate the practical usefulness of WHO classification by correlation of histological subtype of thymoma with staging, symptoms and epidemiology.
MATERIAL AND METHODS: 87 cases of thymomas was reclassified according to the WHO Histologic classification and Masaoka staging system. Clinical symptoms, age and sex of the patient were taken into consideration in each case.
RESULTS: The histological subtypes was diagnosed in order of frequency: AB (n = 21; 24%), B2 (n = 19; 22%), B1 (n = 14; 16%), A (n = 6; 7%), C (n = 4; 5%), B3 (n = 3; 3%). Combined types was observed in 17 (20%) cases. Tendency to invasion increased as follows: A < AB < B1 < B2 < B3 < C. The median value of patients' age was: type A - 67,5 years, type AB - 62 yrs., type B1 - 48 yrs., type B2 - 52 yrs., type B3 - 32 yrs. and type C (thymic carcinoma) - 49,5 yrs. No correlation was found between histological type and sex of patient. The most often clinical symptom - myasthenia, accompanied predominantly B2 thymomas.
CONCLUSIONS: The WHO classification is useful in routine pathologic examination of thymomas, because it enables to distinguish histological subtypes with different clinical representation.
Pneumonol. Alergol. Pol. 2005, 73, 153-159.

Abstract

Thymomas are rare mediastinal tumors that have heterogeneous microscopic morphology and uncertain outcome.
AIM: The aim of the study was to evaluate the practical usefulness of WHO classification by correlation of histological subtype of thymoma with staging, symptoms and epidemiology.
MATERIAL AND METHODS: 87 cases of thymomas was reclassified according to the WHO Histologic classification and Masaoka staging system. Clinical symptoms, age and sex of the patient were taken into consideration in each case.
RESULTS: The histological subtypes was diagnosed in order of frequency: AB (n = 21; 24%), B2 (n = 19; 22%), B1 (n = 14; 16%), A (n = 6; 7%), C (n = 4; 5%), B3 (n = 3; 3%). Combined types was observed in 17 (20%) cases. Tendency to invasion increased as follows: A < AB < B1 < B2 < B3 < C. The median value of patients' age was: type A - 67,5 years, type AB - 62 yrs., type B1 - 48 yrs., type B2 - 52 yrs., type B3 - 32 yrs. and type C (thymic carcinoma) - 49,5 yrs. No correlation was found between histological type and sex of patient. The most often clinical symptom - myasthenia, accompanied predominantly B2 thymomas.
CONCLUSIONS: The WHO classification is useful in routine pathologic examination of thymomas, because it enables to distinguish histological subtypes with different clinical representation.
Pneumonol. Alergol. Pol. 2005, 73, 153-159.
Get Citation

Keywords

thymoma; thymic carcinoma; the WHO histological classification

About this article
Title

Is the microscopic morphology of thymoma of clinical significance?

Journal

Advances in Respiratory Medicine

Issue

Vol 73, No 3-4 (2005)

Pages

153-159

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2005;73(3-4):153-159.

Keywords

thymoma
thymic carcinoma
the WHO histological classification

Authors

Małgorzata Szołkowska
Renata Langfort
Kazimierz Roszkowski-Śliż

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