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Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Macrophage phenotype in induced sputum in asthma subjects

Joanna Hermanowicz-Salamon, Joanna Domagała-Kulawik, Marta Maskey-Warzęchowska, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):101-105.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Macrophages represent the most predominant immune effector cells in the alveolar spaces and conducting airways and are known to express activated phenotype. The study was aimed at assessing the differences in cellular profile and the expression of selected surface markers on sputum macrophages in asthma and healthy subjects. 17 healthy subjects (never smoked) and 10 mild asthma subjects treated with glucocorticosteroids were enrolled into the study. For macrophage phenotyping a immunocytochemistry method was used with commercially available antibodies anti: CD14, CD71, CD11b and CD54. The nonparametric Mann Whitney U test was applied for data comparison, p value

Abstract

Macrophages represent the most predominant immune effector cells in the alveolar spaces and conducting airways and are known to express activated phenotype. The study was aimed at assessing the differences in cellular profile and the expression of selected surface markers on sputum macrophages in asthma and healthy subjects. 17 healthy subjects (never smoked) and 10 mild asthma subjects treated with glucocorticosteroids were enrolled into the study. For macrophage phenotyping a immunocytochemistry method was used with commercially available antibodies anti: CD14, CD71, CD11b and CD54. The nonparametric Mann Whitney U test was applied for data comparison, p value

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Keywords

guinea pigs; dexamethasone; allergy asthma; phosphodiesterase4 inhibitor

About this article
Title

Macrophage phenotype in induced sputum in asthma subjects

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

101-105

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):101-105.

Keywords

guinea pigs
dexamethasone
allergy asthma
phosphodiesterase4 inhibitor

Authors

Joanna Hermanowicz-Salamon
Joanna Domagała-Kulawik
Marta Maskey-Warzęchowska
Ryszarda Chazan

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